摘要
中风是我国致残的首要病因,中医学主要通过四诊辨证中风病,目前尚缺乏辨识中风病不同证候的客观检测指标。本研究以脾肾藏象理论为源,浅析唾液与中风痰湿证的相关性,初探唾液蛋白质组学技术在预测与诊断痰湿证中风病的价值,为临床精准防治中风病提供理论参考。通过检索国内外相关文献,并总结中医古籍中有关“脾在液为涎,肾在液为唾”的理论。发现痰湿同风邪一样,是中风病的主要致病因素和病理产物之一,贯穿中风发生发展的始终;唾液的生成变化与脾肾密切相关,与痰湿的盛衰互为影响;唾液蛋白质组学技术可能是预测与诊断中风病痰湿证的有效方法。微观辨识唾液之变,有可能为防治痰湿型中风提供新思路。
Stroke is the first cause of disability in China.Traditional Chinese medicine mainly treats stroke with the information of"Looking,Listening and Smelling,Inquiring,Pulse Diagnosis".At present,there is a lack of objective detection indicators to identify different syndromes of stroke.Based on the theory of visceral manifestation of spleen and kidney,this study analyzed the correlation between saliva and phlegm-dampness syndrome of stroke,and explored the value of saliva proteomics technology in predicting and diagnosing stroke with phlegm-dampness syndrome,so as to provide theoretical reference for clinical accurate prevention and treatment of stroke and microscopic syndrome differentiation research.By searching the relevant literature at home and abroad,and summing up the theory of"drool being the humor of the spleen and saliva being the humor of the kidney"in the ancient books of traditional Chinese medicine.It is found that phlegm-dampness,which like wind evil,is one of the main pathogenic factor and pathological product of stroke,which runs through the occurrence and development of stroke;the formation and change of saliva is closely related to spleen and kidney and affects each other with the rise and fall of phlegm-dampness;saliva is the outer phase of spleen and kidney,and the change of saliva can reflect the function of spleen and kidney and the change of phlegm-dampness.Salivary proteomics may be an effective method for predicting and diagnosing phlegm-dampness syndrome of apoplexy.Microscopic identification of saliva changes may provide a new idea for the prediction and prevention of phlegm-dampness stroke.
作者
陈辉焕
詹杰
凌珊珊
肖俊杰
陈红霞
Chen Huihuan;Zhan Jie;Ling Shanshan;Xiao Junjie;Chen Hongxia(Clinical Medical College of Acupuncture Moxibustion and Rehabilitation of Guangzhou University of Chinese Medicine,Guangzhou 510304,China;Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases,Guangzhou 510304,China;Zhuhai Hospital of Guangdong Province Hospital of Chinese Medicine,Zhuhai 519000,China;Guangdong Province Hospital of Chinese Medicine,Guangzhou 510304,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2022年第9期3644-3650,共7页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
广东省科学技术厅广东省中医药防治难治性慢病重点实验室(2018年度)(2018B030322012),负责人:陈红霞
广东省中医院沈宝藩学术经验传承工作室(中医二院[2018]101号),负责人:陈红霞
关键词
唾液
痰湿证
缺血性中风
脾在液为涎
肾在液为唾
Saliva
Phlegm-dampness syndrome
Ischemic stroke
Drool being the humor of the spleen
Saliva being the humor of the kidney
作者简介
通讯作者:陈红霞,广东省中医院康复科主任,博士研究生导师,主要研究方向:神经系统的中西医康复治疗。
