摘要
经典名方生脉方由人参、麦冬和五味子三味中药配伍组成,是中药益气养阴生津的代表方。近代根据不同医疗应用相继研制出多种生脉制剂,但是上述制剂的质量标准水平参差不齐,且大多数仅规定了单味药物的个别成分,难以保证临床用药的有效性、安全性。同时近年来随着生脉方的理化鉴别方法不断迭新,对其主要化学成分皂苷类、木脂素类和黄酮类的研究日益完善,但少有针对其成方制剂分析方法的系统性归纳。本文依据现有文献归纳了生脉方中近年来新发现的化合物成分,同时系统性总结生脉方制剂的质量标准及分析方法,以期给经典名方的研究、开发和应用提供参考依据。
Shengmai formula,composed of Ginseng Radix et Rhizoma,Ophiopogon Radix and Schisandrae Chinensis Fructus,is a classic and famous formula.It is a representative formula for"supplementing qi,nourishing yin,and generating fluid"in Traditional Chinese Medicine theory.To date,a wide range of Shengmai formulae have been developed according to different medical applications,but the quality evaluation standards are at a relatively low level,and most of them only specify the individual components of a single herb,making it difficult to ensure clinical efficacy and safety.At the same time,the physical and chemical identification methods of Shengmai formula have been constantly updated,allowing for greater progress in research on its main chemical components such as saponins,lignans and flavonoids.However,there is little systematic summarization of the chemical components and analytical methods.Based on the existing references,we systematically summarized ginsenosides,ophiopogonins,schisandra lignans,homoisoflavonoids and some other compounds in this paper,as well as the quality standards of Shengmai formulae and their analytical methods in order to aid clinical research and formulation manufacture.
作者
钱紫萱
孙雪杨
张辰明
刘龙婵
李林楠
张皓月
杨莉
王峥涛
Qian Zixuan;Sun Xueyang;Zhang Chenming;Liu Longchan;Li Linnan;Zhang Haoyue;Yang Li;Wang Zhengtao(Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine/The MOE Key Laboratory of Standardization of Chinese Medicines/The SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines/Shanghai Key Laboratory of Compound Chinese Medicines,Shanghai 201203,China;School of Pharmacy,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Shanghai R&D Center for Standardization of Chinese Medicines,Shanghai 201203,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2023年第8期2699-2708,共10页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委员会重点项目(82130115):基于质量源于设计理念的“同方异制”生脉、复方丹参方质量评价新策略,负责人:王峥涛
国家自然科学基金委员会面上项目(82074011):人参皂苷立体异构成分快速辨识与绿色分离系统构建及在质量控制中的应用,负责人:杨莉。
关键词
生脉方
经典名方
人参
麦冬
五味子
化学成分
分析方法
Shengmai formula
Classic formula
Ginseng Radix et Rhizoma
Ophiopogon Radix
Schisandrae Chinensis Fructus
Chemical composition
Analytical methods
作者简介
通讯作者:李林楠,博士,副研究员,主要研究方向:中药分析和质量评价新技术;通讯作者:王峥涛,博士,教授,主要研究方向:生药学/中药资源与鉴定、中药功效物质基础、中药标准化及安全性评价研究。
