摘要
目的探究胃癌患者中医证型与发病节气的相关性。方法本研究纳入分析2020年1月-2023年8月广州中医药大学第一附属医院肿瘤中心收治的359例胃癌患者的病例,对其性别、年龄、发病节气、中医证型、分化程度等信息进行统计,探讨胃癌患者的中医证型及胃癌分化程度与发病节气之间是否存在相关性。数据统计分析采用SPSS 25.0软件。结果本研究纳入的359例胃癌患者,男性患者多于女性(1.69∶1),年龄主要集中在60-70岁(117例,32.6%),在此年龄段发病的男性患者(85例,72.6%)亦多于女性患者(32例,27.3%);中医证型占比较高的为气血亏虚证(160例,44.6%)和痰湿凝结证(94例,26.2%);发病主要集中在冬季(132例,36.8%),其中小雪(31例,23.5%),大寒(25例,18.9%),大雪(23例,17.4%)和立冬(22例,16.7%)为发病高峰期。胃癌患者气血亏虚证与痰湿凝结证与节气和季节具有相关性(P<0.05)。285例胃癌患者以低分化胃癌为主(175例,61.4%),主要集中在冬季(66例,37.7%)。胃癌转移途径主要经淋巴结转移,其次为肝和腹腔转移。结论胃癌患者以气血亏虚证、痰湿凝结证多见,其发病时间多发生在冬季,且证型与发病节气、分化程度有显著相关性。
Objective To investigate the correlation between TCM syndrome types and solar term of onset in patients with gastric cancer.Methods A total of 359 patients with gastric cancer admitted to the Cancer Center of the First Affiliated Hospital of Guangzhou University of Chinese Medicine from January 2020 to August 2023 were included in this study,and the frequency distribution method was used to analyze their information such as sex,age,solar term of onset,differentiation,metastasis and TCM syndrome type.The solar term of onset corresponding to the onset date was calculated,and then the association between solar term of onset and TCM syndrome type in gastric cancer was analyzed.The circular distribution method was used to explore the peak of solar term of onset and TCM syndrome type.Results Among the 359 patients with gastric cancer included in this study,male patients were more than female patients(1.69∶1).The age of onset was mainly between 60 and 70 years old(117 cases,32.6%),and male patients(85 cases,72.6%)were more than female patients(32 cases,27.3%)in this age group.The most common TCM syndromes were qi and blood deficiency syndrome(160 cases,44.6%)and phlegm damp condensation syndrome(94 cases,26.2%).The onset of the disease mainly occurred in winter(132 cases,36.8%),and the peaks were light snow(31 cases,23.5%),major cold(25 cases,18.9%),heavy snow(23 cases,17.4%)and the start of winter(22 cases,16.7%).Qi and blood deficiency syndrome and phlegm damp condensation syndrome in patients with gastric cancer were correlated with solar terms and seasons(P<0.05).The 285 patients with gastric cancer were mainly poorly differentiated gastric cancer(175 cases,61.4%),mainly concentrated in winter(66 cases,37.7%).The main route of gastric cancer metastasis is lymph node metastasis,followed by liver and abdominal cavity metastasis.Conclusion Qi and blood deficiency syndrome and phlegm dampness condensation syndrome are common in patients with gastric cancer.The onset time of gastric cancer is mostly in winter,and the syndrome type is significantly correlated with the onset solar term and differentiation degree.
作者
汪显超
李娜
黄静
史培峥
钟晓敏
张新江
王哈林
魏小勇
肖珊珊
叶小卫
杨巧红
Wang Xianchao;Li Na;Huang Jing;Shi Peizheng;Zhong Xiaomin;Zhang Xinjiang;Wang Halin;Wei Xiaoyong;Xiao Shanshan;Ye Xiaowei;Yang Qiaohong(School of Basic Medicine Sciences,Guangzhou University of Chinese Medicine,Guangzhou 510006,China;The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Department of Physiology,Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,Beijing 100700,China;The First Clinical Medical College of Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Research Center for Integrated Medicine of Guangzhou University of Chinese Medicine,Guangzhou 510006,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2023年第10期3384-3393,共10页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
广东省自然科学基金面上项目(2020A1515010017):APS靶向调控PMEPA1抑制胃癌细胞侵袭转移的分子机制研究,负责人:杨巧红
广东省中药新药研发重点实验室开放基金课题(2017B030314096),黄芪多糖靶向调控ID1基因信号通路抗胃癌机制研究,负责人:杨巧红
关键词
胃癌
中医证型
节气
气血亏虚证
痰湿凝结证
Gastric cancer
TCM syndrome type
Solar term
Deficiency of Qi and blood
Phlegm-dampness condensation
作者简介
通讯作者:杨巧红,副教授,硕士研究生导师,主要研究方向:肿瘤分子病理及中西医结合防治消化道肿瘤;叶小卫,主任医师,博士研究生导师,主要研究方向:中西医结合防治消化道肿瘤分子机制研究。
