摘要
M2型丙酮酸激酶(M2 isoform pyruvate kinase,PKM2)是糖酵解途径的关键酶。PKM2在多种肿瘤中高表达,且与肿瘤发生发展密切相关。自噬(autophagy)是一个溶酶体依赖的胞内降解过程。自噬通过对肿瘤细胞葡萄糖摄取、糖酵解途径进行调控,从而影响肿瘤的生物学行为。近年来的研究逐步揭示,PKM2与肿瘤自噬之间可相互调控,PKM2可影响肿瘤自噬的发生和结果,自噬可影响PKM2的活性和蛋白量,且二者的相互作用与病人总体生存率密切相关。这些发现将为针对PKM2及自噬的肿瘤临床治疗带来新的思路。
M2 isoform pyruvate kinase(PKM2)is a key enzyme in the glycolysis pathway.PKM2 is highly expressed in a variety of tumors and closely related to tumor development.Autophagy is a lysosomal dependent intracellular degradation process.Autophagy regulates the glucose uptake and glycolysis of tumor cells,thus affecting the biological behavior of tumor.In recent years,studies have gradually revealed that PKM2 and tumor autophagy can regulate each other.PKM2 can affect the occurrence and results of tumor autophagy.Autophagy can affect the activity and protein quantity of PKM2.And the interaction between PKM2 and autophagy is closely related to the overall survival rate of patients.These findings will bring new ideas for the clinical treatment of PKM2 and autophagy.
作者
周美玲
杨丽娟
朱月春
ZHOU Meiling;YANG Lijuan;ZHU Yuechun(Department of Biochemistry and Molecular Biology,Basic Medical School of Kunming Medical University,Kunming 650500,China)
出处
《生命的化学》
CAS
CSCD
2020年第1期37-42,共6页
Chemistry of Life
基金
国家自然科学基金项目(81760455,81460421,31660246,81560037,81660135)
云南省应用基础研究项目[2017FE468(-132),2017FE468(-003),2018FE468(-001),2017FE468(-141),2018FB-120]
昆明医科大学研究生创新基金项目(2019S001).
作者简介
第一作者:周美玲,E-mail:1055005424@qq.com;通信作者:朱月春,E-mail:zhuyuechun20091119@163.com
