摘要
在中枢神经系统中,周细胞是神经血管单元结构和功能的重要组成部分。周细胞参与缺血性卒中后的一系列炎症反应,具有免疫调节细胞特性,包括吞噬及抗原呈递作用、诱导外周免疫细胞浸润、释放多种炎性因子等。本文综述了脑周细胞的生物学特性及其在缺血性脑卒中免疫炎症反应中的作用,总结了靶向周细胞的治疗策略,为靶向周细胞治疗缺血性脑卒中提供新的研究思路。
In the central nervous system,pericytes are important component of the structure and function of the neurovascular unit.Pericytes are involved in a series of inflammatory responses after ischemic stroke and have immunomodulatory cellular properties,including phagocytosis and antigen presentation,induction of peripheral immune cell infiltration,and release of various inflammatory factors.This review describes the biological properties of pericytes and their role in the immune inflammatory response in ischemic stroke,and summarizes the therapeutic strategies for targeting pericytes,providing new research ideas for targeting pericytes in the treatment of ischemic stroke.
作者
李明玥
于亚君
韩睿
吕玲
张晗
王凯
李霖
LI Mingyue;YU Yajun;HAN Rui;LYU Ling;ZHANG Han;WANG Kai;LI Lin(Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;State Key Laboratory of Component-Based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae,Tianjin University of Traditional Chinese Medicine,Ministry of Education,Tianjin 301617,China;The Second Hospital Affiliated to Tianjin University of Traditional Chinese Medicine,Tianjin 300150,China)
出处
《生命的化学》
CAS
2022年第12期2171-2176,共6页
Chemistry of Life
基金
湖北省科技重大专项(2020ACA019,2021ACA004-03)
关键词
周细胞
缺血性脑卒中
免疫炎症
pericytes
ischemic stroke
immune inflammation
作者简介
第一作者:李明玥,E-mail:lmytjt@163.com;通信作者:李霖,E-mail:lilintcm@126.com
