摘要
在免疫系统中,B细胞通常在免疫反应中发挥正向应答作用,在体液免疫的调节过程中作用巨大,也可以通过分泌抗体在细胞免疫中发挥重要的调控作用。一类特殊的B细胞亚群,即调节性B细胞(Bregs),可通过分泌一些生物活性物质在免疫应答中主要起负向调节作用,被认为是小鼠和人类免疫系统的一个新的重要组成部分。Bregs可以调控包括炎症、感染、自身免疫性疾病以及肿瘤等多种疾病进程的发展,是一种在机体出现免疫功能障碍时发挥重要作用的保护性细胞。本文就Bregs的发现、Bregs分类与功能及其在肿瘤中的研究进展进行综述。
In the immune system,B cells usually play a positive role in the immune response,playing a huge role in the regulation of humoral immunity,and can also play an important role in the regulation of cellular immunity by secreting antibodies.A special subset of B cells,namely,regulatory B cells(Bregs),can play a major negative role in the immune response by secreting some bioactive substances,and is considered to be a new important component of the immune system of mice and humans.Bregs can regulate the development of a variety of diseases,including inflammation,infection,autoimmune diseases and tumors.Bregs are protective cells that play an important role in immune dysfunction.This paper reviews the discovery,classification and function of Bregs and its research progress in tumor.
作者
李新伟
白慧敏
张涛
刘锦龙
LI Xinwei;BAI Huimin;ZHANG Tao;LIU Jinlong(School of Basic Medicine and Forensic Medicine,Baotou Medical College,Baotou 014040,China)
出处
《生命的化学》
CAS
2022年第12期2191-2199,共9页
Chemistry of Life
基金
内蒙古自治区自然科学基金项目(2020LH08006)
关键词
调节性B细胞
分类
肿瘤
免疫应答
regulatory B cells
classification
tumor
immune response
作者简介
第一作者:李新伟,E-mail:1437911537@qq.com;通信作者:刘锦龙,E-mail:liujinlong@btmc.edu.cn
