摘要
目的研究石斛参芝含片增强小鼠免疫力功能的作用。方法本研究设低、中、高3个剂量组,另设蒸馏水阴性对照组,连续给予30d。试验结束时取脾脏和胸腺计算其脏/体比值,并测定足趾肿胀度、淋巴细胞增殖能力、溶血空斑数、抗体水平积数、碳廓清能力、巨噬细胞吞噬率和吞噬指数以及NK细胞活性。结果各剂量组动物的脾脏/体重比值、胸腺/体重比值、淋巴细胞增殖能力、抗体水平积数、碳廓清能力、巨噬细胞吞噬率和吞噬指数、NK细胞活性与阴性对照组之间无显著性差异(P>0.05);3个剂量组动物的足趾肿胀度均高于阴性对照组动物,差异具有统计学意义(P<0.01);3个剂量组动物的溶血空斑数均高于阴性对照组,差异有统计学意义(P<0.01)。结论石斛参芝含片对昆明种小鼠有增强免疫力功能的作用。
Objective To investigate the effects of dendrobium,ginseng and ganoderma tablet on immunity functions of mice.Methods In this study,low,medium and high dose groups were set,and the negative control group of distilled water was set,which was continuously given for 30 days.At the end of the experiment,spleen and thymus were taken,and the organ/body weight ratio of spleen and thymus,paw swelling,ability of lymphocyte proliferation,number of hemolytic plaques,antibody forming ability,ability of carbon clearance,the phagocytosis ratio and phagocytosis index of macrophage,and activity of NK cells were measured.Results There were no significant differences in the organ/body weight ratio of spleen and thymus,ability of lymphocyte proliferation antibody forming ability,ability of carbon clearance,the phagocytosis ratio and phagocytosis index of macrophage,and activity of NK cells between each dosage group and the negative control group(P>0.05).The degree of paw swelling in the 3 dose groups was higher than that in the negative control group,and the difference was statistically significant(P<0.01).The number of hemolytic plaques in the 3 dose groups was higher than that in the negative control group,and the difference was statistically significant(P<0.01).Conclusion Dendrobium,ginseng and ganoderma tablet can strenghten the immunity functions of Kunming mice.
作者
邹思颖
郑华
黄聘和
ZOU Si-Ying;ZHENG Hua;HUANG Pin-He(Chengdu Fifth People’s Hospital,Chengdu 611130,China;Sichuan Center for Disease Control and Prevention,Chengdu 610041,China)
出处
《食品安全质量检测学报》
CAS
2020年第1期86-90,共5页
Journal of Food Safety and Quality
关键词
石斛参芝含片
小鼠
免疫力
dendrobium,ginseng and ganoderma tablet
mice
immunity functions
作者简介
通讯作者:邹思颖,博士,副主任医师,主要研究方向为保健食品的功能性检测,Email:zsyqq666@163.com
