摘要
目的探讨2型糖尿病急性冠脉综合征(ACS)患者脂蛋白相关磷脂酶A2(Lp-PLA2)水平和全球急性冠状动脉事件注册(GRACE)评分及其与主要心血管不良事件(MACE)的关系。方法选取2016-03-01-2020-05-31泰州市中西医结合医院接受治疗的103例2型糖尿病ACS患者为研究对象。所有患者出院后随访90 d,根据是否发生MACE事件分为事件组(n=17)和非事件组(n=86)。比较2组性别、年龄、吸烟、饮酒、收缩压、舒张压、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、同型半胱氨酸(Hcy)水平、药物使用情况、Lp-PLA2水平、GRACE评分。采用多因素分析,筛选患者发生MACE事件的独立危险因素。结果单因素分析结果显示,事件组与非事件组比较,年龄(t=3.067,P<0.001)、性别(t=4.023,P=0.044)、HDL-C(t=5.072,P<0.001)、Lp-PLA2水平(t=8.427,P<0.001)、Hcy水平(t=4.121,P<0.001)和GRACE评分(t=6.470,P<0.001)之间差异有统计学意义。多因素Logistic回归分析结果显示,发生MACE事件的危险因素是Lp-PLA2水平(OR=2.098,95%CI为1.318~3.324,P<0.001)和GRACE评分(OR=2.431,95%CI为1.309~4.513,P<0.001)。结论2型糖尿病ACS患者Lp-PLA2水平升高,与GRACE评分呈正相关。Lp-PLA2水平和GRACE评分是患者发生MACE事件的独立危险因素。
Objective To investigate the level of lipoprotein associated phospholipase A2(Lp-PLA2)and global register of acute coronary events(GRACE)score in patients with type 2 diabetes mellitus with acute coronary syndrome(ACS)and their relationship with major adverse cardiovascular events(MACE).Methods A total of 103 patients with type 2 diabetes ACS who received treatment in Taizhou Hospital of Integrated Chinese and Western Medicine from March 1,2016 to May 31,2020 were selected as the subjects.All patients were followed up for 90 days after discharge.They were divided into event group(n=17)and non event group(n=86).The levels of gender,age,smoking,drinking,systolic blood pressure,diastolic blood pressure,triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),homocysteine(Hcy),drug use,Lp-PLA2 and GRACE score were compared between the two groups.Multivariate analysis was used to screen the independent risk factors of MACE events.Results Univariate analysis showed that there were significant differences in age(t=3.067,P<0.001),gender(t=4.023,P=0.044),HDL-C(t=5.072,P<0.001),Lp-PLA2 level(t=8.427,P<0.001),Hcy level(t=4.121,P<0.001)and GRACE score(t=6.470,P<0.001)between event group and non event group.Multivariate Logistic regression analysis showed that the risk factors of mace events were Lp-PLA2 level(OR=2.098,95%CI:1.318-3.324,P<0.001)and grace score(OR=2.431,95%CI:1.309-4.513,P<0.001).Conclusion The level of Lp-PLA2 in patients with type 2 diabetes mellitus is elevated,and is positively correlated with GRACE score in ACS patients.Lp-PLA2 level and grace score were independent risk factors for mace events.
作者
刘剑峰
陈梅
LIU Jian-feng;CHEN Mei(Department of Geriatric,Taizhou Hospital of Integrated Chinese and Western Medicine,Taizhou 225300,China)
出处
《社区医学杂志》
CAS
2022年第2期83-86,共4页
Journal Of Community Medicine
作者简介
通信作者:刘剑峰,男,江苏泰兴人,副主任医师,主要从事高血压及糖尿病等疾病的诊治研究工作。E-mail:yzca49@163.com
