摘要
目的探讨病原学基因芯片对重症肺炎患者的病原体检出率及其临床治疗策略的影响。方法选取2018-01-01-2020-12-31宁德师范学院附属宁德市医院收治的46例重症肺炎患者作为研究对象,其中进行病原学基因芯片检查和常规培养的重症肺炎患者为观察组(n=21),仅常规培养检测病原学的重症肺炎患者为对照组(n=25)。收集2组患者病原微生物检出率及检出时间、限定日剂量(DDDs)值等临床资料,并进行统计分析。结果观察组病原学检测阳性率为71.4%,高于对照组的28.0%,χ^(2)=8.626,P=0.003;阳性病例检出时间为(15.48±6.65)h,短于对照组的(50.92±17.40)h,t=-9.403,P<0.001。观察组根据病原学检测结果调整抗生素为13例(62.9%),大于对照组的8例(32%),χ^(2)=4.114,P=0.043;观察组抗生素的DDD值为(28.25±11.09),少于对照组的(36.59±11.12),t=-2.197,P=0.033。结论与常规培养相比,病原学基因芯片检测能够提高重症肺炎患者病原菌检出率,从而进行早期抗生素调整,减少抗生素使用强度。
Objective To investigate the effect of pathogenic gene chip on the physical examination rate of pathogens and clinical treatment strategies in patients with severe pneumonia.Methods Totally 46 patients with severe pneumonia treated in Ningde Hospital Affiliated to Ningde Normal University from January 1,2018 to December 31,2020 were selected as the research object.The patients with severe pneumonia who underwent etiological gene chip examination and routine culture were divided into the observation group(n=21),and the patients with severe pneumonia who underwent routine culture only for the detection of etiology were in the control group(n=25).The clinical data such as the detection rate and time of pathogenic microorganisms and the value of defined daily dose(DDDs)in the two groups were collected and statistically analyzed.Results The positive rate of pathogenic test in the observation group was 71.4%,higher than 28.0%in the control group,χ^(2)=8.626,P=0.003;the detection time of positive cases was(15.48±6.65)h,which was shorter than that of the control group(50.92±17.40)h,t=-9.403,P<0.001;the proportion of antibiotics adjustment according to the results of etiological detection was higher than that of control group,13 cases(62.9%)and 8 cases(32%),χ^(2)=4.114,P=0.043.The DDD value of antibiotics in the observation group was(28.25±11.09),less than that in the control group(36.59±11.12),t=-2.197,P=0.033.Conclusions Pathogenic gene chip can increase the detection rate of pathogens,which help the adjustment of antibiotics in the early stage,and reduce the antibiotics does in patients with severe pneumonia compared to conventional culture.
作者
张灿辉
刘志新
吴建辉
彭志文
成英
ZHANG Can-hui;LIU Zhi-xin;WU Jian-hui;PENG Zhi-wen;CHENG Ying(Department of Pulmonary and Critical Care Medicine,Ningde Municipal Hospital of Ningde Normal University,Ningde 352100,China)
出处
《社区医学杂志》
CAS
2022年第6期338-342,共5页
Journal Of Community Medicine
基金
福建省自然科学基金面上项目(2018J01228)
作者简介
第一作者:张灿辉,男,福建福安人,硕士,副主任医师,主要从事感染与重症的临床研究工作。E-mail:luoye123465678@163.com;通信作者:成英,女,山西平遥人,硕士,副主任医师,要从事感染与重症的临床研究工作。E-mail:4720523@163.com
