摘要
提供了一种头孢他啶母液冷冻浓缩处理方案。采用冷冻浓缩技术,以头孢他啶母液为原料,通过内盘管冷冻浓缩装置实现固液分离,得到头孢他啶浓缩母液。冷冻时间在3 h以上、冷冻温度在-5℃以下、初始母液浓度在15~20 mg/mL、结晶母液pH值范围在3.5~3.8时,浓缩液浓度达到25 mg/mL适用于头孢他啶母液套用,可使头孢他啶质量收率提高6.6个百分点,达到91%以上。该技术可有效浓缩头孢他啶母液,既可回收母液中的有效成分头孢他啶,又可降低母液排放的COD与BOD等指标,减少了污染并降低了能耗。
A freeze concentration treatment scheme for ceftazidime mother liquor was put forward.Ceftazidime concentrate mother liquor was obtained from ceftazidime mother liquor by using freeze concentration technology,and solid-liquid separation was realized by inner coil freeze concentration device.When the freezing time was over 3 h,the freezing temperature was below-5℃,the initial mother liquor concentration was 15~20 mg/mL,and the pH value of the crystalline mother liquor was 3.5~3.8,the concentration of the concentrated liquor reached 25 mg/mL,which is suitable for the application of ceftazidime mother liquor.The quality yield of ceftazidime was increased by 6.6%,reaching 91%.The technology can effectively concentrate the mother liquor of ceftazidime.It can not only recover the effective component ceftazidime in mother liquor,but also reduce the COD and BOD of mother liquor discharge,reducing the pollution and energy consumption.
作者
胡利敏
贾全
任峰
田洪年
刘树斌
李庆伟
HU Li-min;JIA Quan;REN Feng;TIAN Hong-nian;LIU Shu-bin;LI Qing-wei(NCPC Hebei Huamin Pharmaceutical Co.,Ltd.,Hebei Shijiazhuang 052165,China)
出处
《当代化工》
CAS
2020年第3期589-592,共4页
Contemporary Chemical Industry
关键词
头孢他啶
冷冻浓缩技术
母液套用
ceftazidime
freeze concentration technology
mother liquor application
作者简介
胡利敏(1972-),男,河北省灵寿人,高级工程师,硕士学位,2016年毕业于沈阳药科大学药学院,研究方向:主要从事药物合成及结晶研究,E-mail:hulimin252@hotmail.com。;通讯作者:贾全(1981-),男,高级工程师,研究方向:主要从事药物合成及结晶研究,E-mail:hcho1101@126.com。;通讯作者:李庆伟(1966-),男,高级工程师,研究方向:主要从事药物合成及结晶研究,E-mail:liqingwei19660816@sina.com。
