摘要
目的探究经皮肾镜和输尿管软镜联合治疗肾结石的有效性并评估治疗后患者的尿激酶水平。方法前瞻性选取2018年10月至2019年10月盘锦市中心医院泌尿外科收治的106例肾结石患者,采用随机数字表法将患者分为常规组(n=53)及研究组(n=53)。常规组患者行单纯经皮肾镜取石术,研究组患者行经皮肾镜和输尿管软镜联合治疗。比较两组患者手术时间、手术次数、穿刺通道数量、治疗后无石率、尿激酶水平和并发症发生情况。结果研究组患者的手术时间(98.39±15.14 min)、手术次数(1.42±0.24次)及穿刺通道数量(0.45±0.01个)均显著少于常规组(112.48±17.07 min、2.09±0.38次、2.59±0.33个),差异具有统计学意义(P<0.05);研究组患者的首次术后无石率(83.02%)显著高于常规组(64.15%),差异有统计学意义(P<0.05);研究组术后无石率(96.23%)与常规组(92.45%)比较,差异无统计学意义(P>0.05)。治疗后,研究组患者的尿激酶水平(1.59±0.26μg/L)显著高于常规组(1.12±0.21μg/L),差异有统计学意义(P<0.05)。研究组患者的总并发症发生率(5.66%)明显低于常规组(18.87%),差异具有统计学意义(P<0.05)。结论与单纯经皮肾镜取石术相比,经皮肾镜和输尿管软镜联合治疗肾结石患者,能够有效缩短手术时间,提高结石清除效果,同时对改善患者尿激酶水平及降低患者治疗期间并发症发生率具有重要意义。
Objective To investigate the effectiveness of the combination of percutaneous nephroscope and soft ureteroscope in the treatment of renal calculi and to evaluate the patients’level of urokinase after treatment.Methods A total of 106 patients with renal calculi admitted in the urology department of Panjin Central Hospital from October 2018 to October 2019 were selected prospectively,and the patients were divided into the conventional group and the research group randomly.Patients in the conventional group underwent simple percutaneous nephrolithotomy,and patients in the study group underwent combined treatment of percutaneous nephroscope and soft ureteroscope.The operation duration time,times of operation,number of puncture channels,stone-free rate after treatment,urokinase level,and incidence of complications were compared between the two groups.Results The operation duration time,times of operation,and number of puncture channels in the study group were(98.39±15.14)min,(1.42±0.24)times,and(0.45±0.01),which were significantly less than those in the conventional group(112.48±17.07)min,(2.09±0.38)times and(2.59±0.33),and the differences were statistically significant(P<0.05).The first postoperative stone-free rate in the study group was 83.02%,which was significantly higher than that in the conventional group(64.15%),and the difference was statistically significance(P<0.05).The postoperative stone-free rate in the study group was 96.23%and 92.45%in the control group,the difference was not statistically significant(P>0.05).After treatment,the urokinase level in the study group was(1.59±0.26)μg/L,which was significantly higher than that in the conventional group(1.12±0.21)μg/L,and the difference was statistically significant(P<0.05).The total incidence of complications in the study group was 5.66%,which was significantly lower than that in the conventional group(18.87%),and the difference was statistically significant(P<0.05).Conclusion Compared with percutaneous nephrolithotomy,the combination of percutaneous nephroscope and soft ureteroscope in the treatment of patients with renal calculi can effectively shorten the operation duration time and improve the effect of stone removal.At the same time,it can improve the urokinase level of patients and reduce the complications during the treatment.
作者
张强
周红丽
陈博君
张健
ZHANG Qiang;ZHOU Hong-li;CHEN Bo-jun(Department of Urology,Panjin Central Hospital,Panjin Liaoning 124010,China;Department of Nephrology,The First Affiliated Hospital of Jinzhou Medical University,Jinzhou Liaoning 121000,China)
出处
《临床和实验医学杂志》
2020年第5期531-534,共4页
Journal of Clinical and Experimental Medicine
基金
辽宁省科技厅科研基金(编号:20170540333).
关键词
肾结石
取石术
经皮肾镜
输尿管软镜
清石率
尿激酶
并发症
Kidney stones
Lithotomy
Percutaneous nephrolithotomy
Soft ureteroscope
Clear stone rate
Urokinase
Complications
作者简介
通讯作者:周红丽,E-mail:zhouhongli77@126.com
