摘要
目的观察阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea syndrome,OSAS)对中年高血压患者糖代谢的影响。方法选择2010年1—12月连续在新疆维吾尔自治区人民医院高血压科就诊的高血压患者,对怀疑有OSAS的患者行夜间多导睡眠监测,获得895例首次诊断OSAS的高血压患者。通过排除标准,选择年龄在40~60岁之间的中年人群进行随访。2017年获得完整随访数据306例,220例合并OSAS的高血压患者(分为轻、中、重度组),未合并OSAS的高血压患者86例。随访内容包括年龄、性别、血压、空腹血糖、糖化血红蛋白、诊断糖尿病的日期及使用降糖药物等,平均随访时间为(4.41±2.44)年。分析中年高血压患者,合并OSAS后发生糖代谢紊乱的情况,高血压合并不同严重程度的OSAS患者经过随访后空腹血糖及糖化血红蛋白水平的差异。结果在中年人群中,高血压合并OSAS组患者糖尿病发病率为18.6%,糖代谢紊乱的发病率为28.6%,均高于未合并OSAS组的高血压患者(8.1%,23.3%)。未合并OSAS组的高血压患者糖尿病前期的发病率(15.1%)高于合并OSAS组患者(10.0%)。结论高血压合并OSAS后更容易发生糖代谢紊乱,糖代谢紊乱的发生率与OSAS的严重程度正相关。
Objective To observe the influence of obstructive sleep apnea syndrome(OSAS)on glucose metabolism in middle-aged hypertensive patients.Methods The whole-night polysomnography(PSG)was performed in the hypertensive patients suspected of OSAS in our department between January to December 2010,and 895 patients were confirmed.According to exclusion criteria,middle-aged people aged between 40 and 60 were selected for follow-up.A total of 306 complete follow-up data were collected in 2017,including 86 patients without OSAS and 220 patients with OSAS(they were divided into mild,moderate and severe groups according to sleep respiratory disorder index(AHI)of OSAS patients).The follow-up included age,sex,blood pressure,fasting blood sugar,glycosylated hemoglobin,date of diabetes diagnosis and use of hypoglycemic drugs.The average follow-up time was(4.41±2.44)years.The incidence of glycometabolism disorder,the average fasting blood glucose and glycosylated hemoglobin level were compared among the different groups.Results Among middle-aged people,the incidence of diabetes mellitus and glucose metabolism disorder was 18.6%and 28.6%respectively in patients with hypertension and OSAS,which were higher than those in hypertension patients without OSAS(8.1%and 23.3%).The incidence of pre-diabetes in hypertension patients without OSAS(15.1%)was higher than that in hypertension patients with OSAS(10.0%).Conclusion The glycometabolism disorder is more likely to occur in hypertensive patients with OSAS.The incidence of glycometabolism disorder is positively correlated with the severity of OSAS.
作者
石阿敏
姚晓光
李南方
努尔古丽·买买提
祖菲亚·阿布利克木
SHI A-min;YAO Xiao-guang;LI Nan-fang;Nuerguli Maimaiti;Zufeiya Abulikemu(Department of Cardiology,The People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi,Xinjiang 830001,China)
出处
《中华全科医学》
2020年第1期62-67,共6页
Chinese Journal of General Practice
基金
新疆少数民族科技人才特殊培养计划(2016D0229)
新疆维吾尔自治区人民医院院内科研项目(20160201).
作者简介
通信作者:李南方,E-mail:Lnanfang@vip.126.com
