摘要
目的对费菜(Sedum aizoon L.)茎叶正丁醇萃取物的化学成分进行研究。方法采用硅胶柱色谱、ODS柱色谱、Sephadex LH-20柱色谱和HPLC分离纯化,依据理化性质和光谱数据确定化合物的结构。结果从费菜茎叶体积分数为70%的乙醇提取物的正丁醇层分离鉴定了13个单体化合物,分别为苯乙醇-O-β-D-葡萄糖苷(benzylethyl-O-β-D-glucopyranoside,1)、vanilloloside(2)、苯乙醇-O-β-D-吡喃木糖-(1→2)-β-D-吡喃葡萄糖苷(benzylethyl-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside,3)、1-氰基-3-O-β-D-吡喃葡萄糖-(Z)-1-甲基-1-丙烯(1-cyano-3-O-β-D-glucopyranosyloxy-(Z)-1-methyl-1-propene,4)、7-O-没食子酰-D-景天庚酮糖(7-O-galloyl-D-sedoheptulose,5)、表百脉根苷(epilotaustralin,6)、蒺藜酸(terrestric acid,7)、cinnamoside(8)、inotodisaccharide(9)、β-D-glucopyranosyl-(1→3)-arbutin(10)、3-O-[α-L-arabinopyranosyl(1→6)-β-D-glucopyranosyl]-5-hydroxymegastigma-6,7-dien-9-one(11)、roseoside(12)and vomifoliol-3′-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside(13)。结论化合物5-13为首次从景天属植物中分离得到。
Objective To study the chemical constituents from n-BuOH extracts of the stems and leaves of Sedum aizoon L.Methods The compounds were isolated and purificated by various isolation methods,such as silica gel,ODS,SephadexLH-20 and HPLC.The structures were identified by measuring the physicochemical property and spectral data.Results Thirteen compounds were isolated and identified as benzylethyl-O-β-D-glucopyranoside(1),vanilloloside(2),benzylethyl-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside(3),1-cyano-3-O-β-D-glucopyranosyloxy-(Z)-1-methyl-1-propene(4),7-O-galloyl-D-sedoheptulose(5),epilotaustralin(6),terrestric acid(7),cinnamoside(8),inotodisaccharide(9),β-D-glucopyranosyl-(1→3)-arbutin(10),3-O-[α-L-arabinopyranosyl(1→6)-β-D-glucopyranosyl]-5-hydroxymegastigma-6,7-dien-9-one(11),roseoside(12)and vomifoliol-3′-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside(13).Conclusion Compounds 5-13 are isolated from Sedum genus for the first time.
作者
李乔
于洋
徐昙烨
李明晓
吕重宁
路金才
LI Qiao;YU Yang;XU Tanye;LI Mingxiao;LYU Chongning;LU Jincai(The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China;School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China;College of Food Science and Engineering,Dalian Ocean University,Dalian 116023,China)
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2020年第3期240-245,共6页
Journal of Shenyang Pharmaceutical University
基金
辽宁省自然科学基金计划重点项目(20180530034).
关键词
费菜
化学成分
结构鉴定
Sedum aizoon L.
chemical constituent
structure identification
作者简介
李乔(1984-),女(汉族),辽宁沈阳人,主管中药师,硕士,主要从事中药药效基础的研究工作,Tel.13840475012,E-mail:lq-sy@163.com;通信作者:路金才(1971-),男(汉族),黑龙江绥化人,教授,博士,主要从事中药资源的开发与利用工作,Tel.02443520728,E-mail:jincailu@126.com。
