摘要
目的探讨新冠疫情防控前后住院儿童呼吸道合胞病毒(respiratory syncytial virus,RSV)感染的流行病学特征。方法收集2018年1月1日—2021年12月31日就诊于湖南省人民医院临床拟诊断为呼吸道感染入住儿童医学中心儿童的鼻咽拭子标本,采用直接免疫荧光法检测7种常见呼吸道病毒,对数据进行统计学分析。2019年12月31日作为时间节点将数据分为新冠疫情防控前后。结果检出率第一的病原为RSV 11.63%,其次是副流感病毒3为3.90%及腺病毒2.32%;新冠疫情防控前后RSV阳性检出率分别为10.27%、13.80%,差异有统计学意义(χ^(2)=94.211,P<0.001);年龄越小,RSV阳性检出率越高,且新冠疫情防控前后患儿年龄占比发生了变化;男性患儿中RSV检出率为12.01%,女性患儿为11.05%(χ^(2)=7.141,P<0.01),不同性别RSV感染率存在差异,但占比差异无统计学意义(χ^(2)=0.085,P>0.05);防控前RSV检出率存在明显的季节性,5—10月为RSV低谷期,11月开始呈明显上升趋势,12、1、2月为高峰期;防控后RSV检出率低谷期提前至2020年3—8月出现,而2020年10月—2021年7月出现了持续波动的小高峰,其季节性被打乱。结论新冠疫情防控初期降低了RSV病毒的感染,但随着防控政策的放松,RSV再次卷土重来,有全年流行的趋势,全年都应加强RSV的检测,以尽早控制传染源。
Objective To explore the epidemiological characteristics of respiratory syncytial virus(RSV)infection in hospitalized children before and after prevention and control of the SARS-CoV-2 epidemic.Methods We collected nasopharyngeal swab specimens from clinically suspected respiratory tract infection children admitted to Children’s Medical Center of Hunan Provincial People’s Hospital from January 1,2018 to December 31,2021,and seven common respiratory viruses were detected by direct immunofluorescence method.The detection data were statistically analyzed.The date December 31,2019 was used as the time point to divide the data into data before and after prevention and control of the SARS-CoV-2 epidemic.Results The first pathogen detected was respiratory syncytial virus(11.63%),followed by parainfluenza virus 3(3.90%)and adenovirus(2.32%).There was a statistically significant difference in the positive detection rate of RSV before and after prevention and control of the SARS-CoV-2 epidemic(10.27%vs.13.80%,χ^(2)=94.211,P<0.001).The younger the age,the higher the detection rate of RSV,moreover,the age percentages of hospitalized children before and after prevention and control of the SARS-CoV-2 epidemic had changed.The detection rate of RSV was 12.01%in male children and 11.05%in female ones,and there was a difference in the RSV infection rate between the genders(χ^(2)=7.141,P<0.01),but no difference was found in the percentage(χ^(2)=0.085,P>0.05).There was a clear seasonality in the RSV detection rate before the prevention and control,with a trough of RSV detection rate in May-October,a clear upward trend from November,and peaks in December,January and February.The trough of RSV detection rate after the prevention and control was advanced to March-August 2020,but a small peak of continuous fluctuation occurred from October 2020 to July 2021,and its seasonality was disrupted.Conclusion The RSV infection was reduced during the initial period of prevention and control of the SARS-CoV-2 epidemic,but with the relaxation of prevention and control policies,RSV resurfaced with a trend of year-round epidemic.Testing for RSV should be enhanced throughout the year so as to control the source of infection as early as possible.
作者
安雨灵
钟礼立
彭力
林小娟
AN Yuling;ZHONG Lili;PENG Li;LIN Xiaojuan(Hunan Provincial Key Laboratory for Pediatric Respirology,the First Affiliated Hospital of Hunan Normal University/Hunan Provincial People’s Hospital,Changsha,Hunan 410002,China)
出处
《实用预防医学》
CAS
2024年第1期9-12,共4页
Practical Preventive Medicine
基金
湖南省人民医院仁术基金一般项目(RS2022B03)
湖南省卫生健康委科研计划课题(百日咳杆菌感染后儿童外围血中裂隙细胞形态及流式细胞检测的研究)
关键词
儿童
呼吸道合胞病毒
流行特征
新型冠状病毒
疫情防控
children
respiratory syncytial virus
epidemic characteristic
SARS-CoV-2
epidemic prevention and control
作者简介
安雨灵(1997-),硕士生在读,研究方向:儿童呼吸疾病,儿童保健;通信作者:林小娟,E-mail:42271640@qq.com。
