摘要
目的分析脓毒症所致多脏器功能衰竭病患采取不同血液净化模式的疗效差异。方法选取2020年1月至2020年12月本院收治的脓毒症所致多脏器功能衰竭病患共68例作为研究对象,依据随机数表法将其划分成两组,每组各34例,对照组予以连续静脉-静脉血液滤过(CVVH),观察组予以脉冲高容量血液滤过(PHVHF),统计并比较两组治疗前后的急性生理学和慢性健康情况II(APACHE II)评分、血肌酐(Scr)、尿素氮(BUN)、谷丙转氨酶(ALT)、天门冬氨酸氨基转移酶(AST)、白细胞计数(WBC)、平均动脉压(MAP)、心率(HR)、体温及动脉血氧分压(PaO2)水平。结果治疗前,两组APACHE II评分、Scr、BUN、ALT、AST、WBC、MAP、HR、体温以及PaO2水平对比无显著差异(P>0.05);治疗后,观察组APACHE II评分、Scr、BUN、ALT、AST、WBC、MAP、HR及体温低于对照组,PaO2水平高于对照组(P<0.05)。结论CVVH和PHVHF对脓毒症所致多脏器功能衰竭病患均有一定疗效,但后者较前者疗效更佳,更可改善患者的生命体征、肝肾功能以及血气分析等指标,以减轻其炎症反应。
Objective This paper aims to analyze the clinical effectiveness of different blood purification modes in sepsis patients with multiple organ dysfunction syndrome.Methods A total of 68 sepsis patients with multiple organ dysfunction syndrome treated from January 2020 to December 2020 in our hospital were selected as research subjects.According to a random number table,patients were divided into two groups,34 cases in each group.The continuous veno-venous hemofiltration(CVVH)was performed in the control group;the pulse high-volume hemofiltration(PHVHF)was performed in the observation group.Acute physiology and chronic health evaluation II(APACHE II)scores,serum creatinine(Scr),blood urea nitrogen(BUN),alanine transaminase(ALT),aspartate aminotransferase(AST),white blood cell count(WBC),mean arterial pressure(MAP),heart rate(HR),body temperature and arterial partial pressure of oxygen(PaO2)in two groups before and after treatment were compared.Results Before treatment,there were no significant differences between the two groups in APACHE II scores,Scr,BUN,ALT,AST,WBC,MAP,HR,PaO2 levels and body temperature(P>0.05);after treatment,APACHE II scores,Scr,BUN,ALT,AST,WBC,MAP,HR levels and body temperature in the observation group were significantly lower than those in the control group;PaO2 levels were higher than that in the control group(P<0.05).Conclusion Both CVVH and PHVHF have fair effects on the treatment of sepsis with multiple organ dysfunction syndrome;however,PHVHF can better reduce the inflammation response,and improve the patient’s curative effects,vital signs,hepatic and renal function and arterial blood gas analysis indicators.
作者
庞娟
袁野
朱锦奎
PANG Juan;YUAN Ye;ZHU Jin-kui(Guangdong Provincial People’s Hospital Zhuhai Hospital(Zhuhai Golden Bay Center Hospital),Zhuhai Guangdong 519040,China)
出处
《透析与人工器官》
2021年第2期12-14,共3页
Chinese Journal of Dialysis and Artificial Organs
关键词
多脏器功能衰竭
脓毒症
血液净化模式
血液滤过
multiple organ dysfunction syndrome
sepsis
blood purification modes
hemofiltration
作者简介
庞娟(1981-),女,硕士研究生,副主任医师。从事肾内科及血透工作。
