摘要
葡萄膜炎是一种常见眼病,其发病机制多与自身免疫反应有关,可引起严重的视功能损害。在自身免疫性葡萄膜炎及实验性葡萄膜炎模型中均发现了1型辅助T(Th1)细胞、Th17细胞参与疾病发生,且Th17细胞被发现与疾病的复发密切相关。调节性T细胞(Treg)参与炎症反应的消退,其功能及比例的失调是葡萄膜炎迁延不愈的重要原因。Th17细胞与Treg在一定条件下可以相互转化,通过调节Th17细胞/Treg平衡以缓解炎症也成为葡萄膜炎治疗的新途径。
Uveitis is a common ocular disease and may cause serious damage of visual function.The pathogenesis of uveitis is closely related to its autoimmune response.The Th1 cells and Th17 cells were identified to play a key role in the occurrence of autoimmune uveitis and experimental autoimmune uveitis,whilst the Th17 cells were found to be closely associated with disease recurrence.The regulatory T cells(Tregs)were found to be involved in the regression of inflammation.The dysfunction and ratio of Tregs were the major causes for persistence and recurrence of uveitis.Th17 cells and Tregs can also interconvert with each other under certain conditions.Regulating the Th17/Tregs balance might be a potential novel approach to alleviating inflammation and hence providing the treatment for uveitis.
作者
杨明
何笑英
韩伟
YANG Ming;HE Xiaoying;HAN Wei(Eye Center,Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China)
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2023年第1期81-87,共7页
Chinese Journal of Cellular and Molecular Immunology
基金
国家自然科学基金(81670842)
作者简介
杨明(1997-),女,湖南张家界人,硕士研究生,Tel:17816860670,E-mail:yangming1110@zju.edu.cn;通讯作者:韩伟,E-mail:hanweidr@zju.edu.cn
