摘要
胶质瘤是中枢神经系统最为常见的恶性肿瘤,呈侵袭性生长,临床难以治愈。近10余年来,手术切除联合同步放化疗和免疫检查点抑制剂的治疗策略取得一定进展,但疗效仍不甚理想,可能与胶质瘤细胞免疫原性较低和肿瘤免疫抑制微环境有关。肿瘤微环境中免疫细胞与胶质瘤细胞及其他激增细胞共同竞争营养物质,竞争过程中产生的代谢产物又可影响免疫细胞分化和功能。本文拟对近年来有关胶质瘤代谢调控与肿瘤免疫抑制微环境的研究进展进行总结,以期为研究肿瘤发生发展机制和胶质瘤治疗提供新的思路。
Glioma is the most common malignant tumor of the central nervous system,and it is difficult to cure.The growth of malignant glioma is invasive.In recent decades,the strategy of surgical resection combined with concurrent radiotherapy and chemotheraphy,and immunocheckpoint inhibitors have been made progress.However,the therapeutic effect is still not ideal,which may be related to the low immunogenicity of tumor cells and the immunosuppression of tumor microenvironment(TME).In the TME,immune cells compete with glioma cells and other proliferating cells for nutrients,while metabolites in the TME affect the differentiation and functions of immune cells.This article summarizes the research progress of glioma metabolism regulation and tumor immunosuppressive microenvironment in recent years,which provides new ideas for the study of the mechanism of tumor progression and glioma of treatment.
作者
张一鸣
于圣平
刘沛东
李涛
张亮
解杨
李佳博
张锦浩
樊晓光
杨学军
ZHANG Yi ming;YU Sheng ping;LIU Pei dong;LI Tao;ZHANG Liang;XIE Yang;LI Jia bo;ZHANG Jin hao;FAN Xiao guang;YANG Xue jun(Department of Neurosurgery,Tianjin Medical University General Hospital,Tianjin 300052,China)
出处
《中国现代神经疾病杂志》
CAS
北大核心
2020年第2期73-78,共6页
Chinese Journal of Contemporary Neurology and Neurosurgery
关键词
神经胶质瘤
肿瘤微环境
肿瘤干细胞
免疫
细胞
综述
Glioma
Tumor microenvironment
Neoplastic stem cells
Immunity,cellular
Review
作者简介
通讯作者:杨学军,Email:ydenny@126.com
