摘要
脑深部电刺激术最早用于治疗特发性震颤,之后逐渐用于中晚期帕金森病、药物难治性肌张力障碍、其他类型震颤和抽动秽语综合征的治疗,可长期改善临床症状、提高生活质量,是近30余年运动障碍性疾病外科治疗的重大进展。然而脑深部电刺激术存在无法有效改善帕金森病中轴系统症状和继发性肌张力障碍等局限,以及诱发认知功能障碍和步态平衡障碍等不良事件。近年来,脑深部电刺激术刺激靶点和设备技术的革新进一步推动了该疗法在运动障碍性疾病中的应用。
Deep brain stimulation(DBS)was first used in the treatment of essential tremor in 1987,and later used in the treatment of advanced Parkinson’s disease(PD),drug-refractory dystonia,other types of tremor and Tourette’s syndrome,which can reduce the clinical symptoms and improve quality of life of patients for a long time,as a major progress in surgical treatment of movement disorders in past 30 years.However,there are also limitations that can not effectively improve the axial system symptoms of PD,secondary dystonia,or related side effects such as cognitive impairment and balance disorder.In recent years,the exploration of new targets and innovation of DBS equipment have further promoted the treatment of DBS for movement disorders.This article reviews relevant research to provide clinical guidance.
作者
牛朝诗
熊赤
NIU Chao-shi;XIONG Chi(Department of Neurosurgery,The First Affiliated Hospital of University of Science and Technology of China,Anhui Provincial Stereotactic Neurosurgical Institute,Anhui Province Key Laboratory of Brain Function and Brain Disease,Hefei 230001,Anhui,China)
出处
《中国现代神经疾病杂志》
CAS
北大核心
2020年第12期1027-1031,共5页
Chinese Journal of Contemporary Neurology and Neurosurgery
基金
中央引导地方科技创新专项项目(项目编号:2019b07030001)
作者简介
通讯作者:牛朝诗,Email:niuchaoshi@163.com
