摘要
目的:通过正交试验设计方法优化何首乌黑豆酒炙的炮制工艺,为炮制工艺的合理性提供科学依据。方法:在炖制时间、自然放凉时间和干燥温度3个炮制工艺参数下,采用L_(9)(3^(4))正交实验,以二苯乙烯苷、游离蒽醌(大黄素和大黄素甲醚)含量为考察指标,进行炮制工艺优化。结果:优化所得最佳炮制工艺为:炖制12h,自然放凉8h,干燥温度为80℃。结论:优化后的炮制工艺稳定,可连续生产出合格产品,优化的炮制工艺结果可靠。
Objective:Using orthogonal design to optimize the technologies of processing in Polygoni Multiflori Radix Braised by Semen Sojae Atricolor and huang jiu,and provide scientific basis for the rationality of processing technology.Methods:The preparation factors of braising time,cooling time and drying temperature were optimized by using orthogonal design L_(9)(3^(4))which the colligation score of target contenting 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucosidein and free anthraquinones(emodin and physcion).Results:The fairest processing by optimized were braising for 12 hours,Cooling naturally by 8 hours,drying at 80℃.Conclusion:The optimized processing is stabilizing,and qualified products were manufactured uninterruptedly.The optimize processing technology is reliable.
作者
李正刚
曲涵婷
李本淳
王路宏
赵艳
Li Zhenggang;Qu Hanting;Li Benchun;Wang Luhong;Zhao Yan(Siping Institute for Food and Drug Control,Siping 136000,China;Siping Social Psychiatric Hospital,Siping 136000,China)
出处
《亚太传统医药》
2021年第6期37-40,共4页
Asia-Pacific Traditional Medicine
基金
吉林省药品监督管理局吉林省地方中药炮制规范(JLPZGF-2020-014)
关键词
何首乌
炮制
正交实验设计
综合评分
Polygoni Multiflori Radix
Processing
Orthogonal Design
Colligation Score
作者简介
李正刚(1982-),男,吉林省四平市食品药品检验所主管药师,研究方向为中药质量标准。E-mail:1011403708@qq.com;通讯作者:赵艳(1966-),女,吉林省四平市食品药品检验所主任药师,研究方向为药品质量控制及质量标准。E-mail:945473345@qq.com
