摘要
直接口服抗凝药(包括阿哌沙班、达比加群、依度沙班和利伐沙班)与传统抗凝药物相比,出血风险更低,且不需要监测凝血功能。目前关于这两类药物之间发生相互作用及其机制的研究较少,但其都可以通过细胞色素P450酶系和P-糖蛋白对其他药物产生影响,潜在的相互作用可能会增加与直接口服抗凝药相关出血的风险或降低其抗血栓作用,同时也能增加癫痫发作的风险。对抗癫痫药物与直接口服抗凝药药动学相互作用的研究进展进行综述,以期为安全用药提供依据。
Direct oral anticoagulants,namely apixaban,dabigatran,edoxaban,and rivaroxaban,which are considered to be associated to lower bleeding risk than classical anticoagulants,and do not require coagulation monitoring.At present,there was few studies on the interaction and mechanism between the two drugs,but both drugs can affect other drugs through cytochrome P450 enzyme system and P-glycoprotein.The progress of pharmacokinetic interaction between antiepileptic drugs and direct oral anticoagulants iwas reviewed,in order to provide a basis for the safe use of these drugs.
作者
刘玉霞
吕光辉
卢伟
陈黎
LIU Yuxia;LüGuanghui;LU Wei;CHEN Li(Department of Pharmacy,Shiyan City Taihe Hospital Affiliated to Hubei University of Medicine,Shiyan 442000,China)
出处
《药物评价研究》
CAS
2020年第2期345-348,共4页
Drug Evaluation Research
关键词
直接口服抗凝药
抗癫痫药
药物相互作用
direct oral anticoagulants
antiepileptic drugs
interaction of drug
作者简介
第一作者:刘玉霞,学士,药师,研究方向为医院药学,Tel:(0719)8801364,E-mal:1083947919@qq.com;通信作者:陈黎,博士,主任药师,研究方向为医院药学,Tel:(0719)8801148,E-mal:chenli0201@sina.com
