摘要
目的探讨多西他赛化疗所致过敏反应和体液潴留与地塞米松给药剂量和给药方案之间的关系,以期为临床提供一定参考。方法对重庆医科大学附属第三医院2016年5月—2019年2月因多西他赛化疗所致的过敏反应和体液潴留进行回顾性分析,总结过敏反应和体液潴留临床特点、相关因素、治疗措施及转归。结果共搜集247例使用多西他赛化疗患者,发生过敏反应和体液潴留患者分别为11例(4.45%)和10例(4.05%),其中过敏反应与患者是否存在过敏史具有统计意义(P<0.05),过敏反应发生率随地塞米松剂量增大而降低,但无统计意义;体液潴留的发生与地塞米松给药剂量和给药方案相关(P<0.05),低剂量地塞米松预处理时发生率最低。结论针对多西他赛化疗所致过敏反应和体液潴留,应给予有效预处理,降低发生率,提高患者耐受性。
Objective To explore the relationship between the allergic reaction and fluid retention induced by docetaxel chemotherapy,and dexamethasone dose and regimen,in order to provide some reference for clinical practice.Methods A retrospective analysis of allergic reaction and fluid retention caused by docetaxel from May 2016 to February 2019 in the Third Affiliated Hospital of CQMU was conducted,in order to summarize the clinical features,related factors,treatment measures and outcomes of allergic reaction and fluid retention.Results A total of 247 patients were treated with docetaxel.Allergic reaction and fluid retention occurred in 4.45%and 4.05%of patients,respectively.There is significant difference between allergic reaction and allergic history(P<0.05).The incidence of allergic reaction decreased with increasing dose of dexamethasone,but it was not statistically significant.The incidence of fluid retention was not only related to the dose of dexamethasone,but also the administration schedule(P<0.05).The incidence of fluid retention decreased with decreasing dose of dexamethasone.Conclusion For the allergic reaction and fluid retention caused by docetaxel chemotherapy,effective pretreatment should be given to reduce the incidence and improve patient tolerance.
作者
黄贵丽
奚鑫
董杰
罗则华
杜倩
HUANG Guili;XI Xin;DONG Jie;LUO Zehua;DU Qian(Department of Pharmacy,the Third Affiliated Hospital of CQMU,Chongqing 401120,China)
出处
《药物评价研究》
CAS
2020年第3期527-531,共5页
Drug Evaluation Research
关键词
多西他赛
过敏反应
体液潴留
回顾性分析
docetaxel
allergic reaction
fluid retention
retrospective analysis
作者简介
第一作者:黄贵丽(1990-),女,贵州人,药师,硕士,研究方向为临床药学及药理学,E-mail:huangguili@hospital.cqmu.edu.cn;通信作者:杜倩,E-mail:duqian@hospital.cqmu.edu.cn
