摘要
Herpes simplex virus type 1(HSV-1),a neurotropic herpes virus,is able to establish a lifelong latent infection in the human host.Following primary replication in mucosal epithelial cells,the virus can enter sensory neurons innervating peripheral tissues via nerve termini.The viral genome is then transported to the nucleus where it can be maintained without producing infectious progeny,and thus latency is established in the cell.Yin-Yang balance is an essential concept in traditional Chinese medicine(TCM)theory.Yin represents stable and inhibitory factors,and Yang represents the active and aggressive factors.When the organism is exposed to stress,especially psychological stress caused by emotional stimulation,the Yin-Yang balance is disturbed and the virus can re-engage in productive replication,resulting in recurrent diseases.Therefore,a better understanding of the stress-induced susceptibility to HSV-1 primary infection and reactivation is needed and will provide helpful insights into the effective control and treatment of HSV-1.Here we reviewed the recent advances in the studies of HSV-1 susceptibility,latency and reactivation.We included mechanisms involved in primary infection and the regulation of latency and described how stress-induced changes increase the susceptibility to primary and recurrent infections.
Herpes simplex virus type 1(HSV-1),a neurotropic herpes virus,is able to establish a lifelong latent infection in the human host.Following primary replication in mucosal epithelial cells,the virus can enter sensory neurons innervating peripheral tissues via nerve termini.The viral genome is then transported to the nucleus where it can be maintained without producing infectious progeny,and thus latency is established in the cell.Yin-Yang balance is an essential concept in traditional Chinese medicine(TCM) theory.Yin represents stable and inhibitory factors,and Yang represents the active and aggressive factors.When the organism is exposed to stress,especially psychological stress caused by emotional stimulation,the Yin-Yang balance is disturbed and the virus can re-engage in productive replication,resulting in recurrent diseases.Therefore,a better understanding of the stress-induced susceptibility to HSV-1 primary infection and reactivation is needed and will provide helpful insights into the effective control and treatment of HSV-1.Here we reviewed the recent advances in the studies of HSV-1 susceptibility,latency and reactivation.We included mechanisms involved in primary infection and the regulation of latency and described how stress-induced changes increase the susceptibility to primary and recurrent infections.
基金
supported,in part,by the National Key Research and Development Program of China,China(grant number2017YFC1700404)
Natural Science Foundation of China,China(grant numbers 81622050,81573675,81673709,81560661 and81873209)
the Young Top-notch Talent Support Program of Guangdong Province,China(grant numbers 2014TQ01R229 and2016TQ03R586)
Guangdong Province Ocean and Fisheries Bureau-Key Technology Research and Development Program,China(grant number A201701A02)
Guangdong Science and Technology Foundation for Distinguished Young Scholars,China(grant number 2017A030306004)
the Science and Technology Program of Guangzhou,China(grant numbers 201604046016 and201610010182).
作者简介
Corresponding authors:Hiroshi Kurihara,Tel./fax:+862085221559.E-mail addresses:hiroshi_kurihara@163.com;Corresponding authors:Yi-Fang Li,E-mail addresses:liyifang706@jnu.eclu.cn;Corresponding authors:Rong-Rong He,E-mail addresses:rongronghe@jnu.edu.cn.
