Small interfering RNA for cancer treatment:overcoming hurdles in delivery 被引量：22

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摘要 In many ways,cancer cells are different from healthy cells.A lot of tactical nano-based drug delivery systems are based on the difference between cancer and healthy cells.Currently,nanotechnology-based delivery systems are the most promising tool to deliver DNA-based products to cancer cells.This review aims to highlight the latest development in the lipids and polymeric nanocarrier for siRNA delivery to the cancer cells.It also provides the necessary information about siRNA development and its mechanism of action.Overall,this review gives us a clear picture of lipid and polymer-based drug delivery systems,which in the future could form the base to translate the basic siRNA biology into siRNA-based cancer therapies.

作者 Nitin Bharat Charbe Nikhil D.Amnerkar B.Ramesh Murtaza M.Tambuwala Hamid A.Bakshi Alaa A.A.Aljabali Saurabh C.Khadse Rajendran Satheeshkumar Saurabh Satija Meenu Metha Dinesh Kumar Chellappan Garima Shrivastava Gaurav Gupta Poonam Negi Kamal Dua Flavia C.Zacconin

机构地区 Departamento de Quimica Orgánica Sri Adichunchunagiri College of Pharmacy Adv V.R.Manohar Institute of Diploma in Pharmacy School of Pharmacy and Pharmaceutical Science Faculty of Pharmacy Department of Pharmaceutical Chemistry Discipline of Pharmacy School of Pharmaceutical Sciences Department of Life Sciences Department of Biochemical Engineering and Biotechnology School of Pharmacy School of Pharmaceutical Sciences Priority Research Centre for Healthy Lungs Institute for Biological and Medical Engineering

出处《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2020年第11期2075-2109,共35页 药学学报（英文版）

基金 “CONICYT FONDECYT POSTDOCTORADO FELLOWSHIP 2018,PROYECTO N°3180250”

关键词 Small interfering RNA(siRNA) NANOMEDICINE Liposomes Micelles CANCER POLYMER

分类号 R730.5 [医药卫生—肿瘤]

作者简介 Corresponding authors:Nitin Bharat Charbe,E-mail addresses:Nitinunimi@gmail.com;Corresponding authors:Flavia C.Zacconi,E-mail addresses:fzacconi@uc.cl

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