摘要
一氧化氮(NO)广泛存在于外周和中枢神经系统中,调节多种生理功能。睡眠-觉醒是机体的高级生理活动,研究表明,NO参与机体睡眠觉醒的调控。精氨酸在一氧化氮合酶(NOS)的作用下转变成瓜氨酸并产生NO,NO通过作用于鸟苷酸环化酶或亚硝基化蛋白质中特定氨基酸残基的途径,影响上行网状激活系统的活性,从而实现对睡眠觉醒进程的调控。本文主要对NO的产生、在睡眠觉醒和上行网状激活系统中的作用及其机制进行综述,为睡眠觉醒的研究提供新的思路和方向。
Nitric oxide(NO)is widely present in peripheral and central nervous system and regulates many physiological functions.Sleep-arousal is an advanced physiological activity.Studies have shown that NO is involved in the regulation of sleep and arousal.Nitric oxide synthases(NOSs)are a family of enzymes that catalyze the production of NO from L-arginine.Through guanylate cyclase or S-nitrosation of protein,NO can affect the activity of the ascending reticular activating system to regulate the sleep-arousal process.This paper summarizes the production of NO,its effect on sleep-arousal and its mechanism in the ascending reticular activating system,and provides new ideas and directions for the study of sleep and arousal.
作者
于凤婷
张建军
YU Feng-ting;ZHANG Jian-jun(Beijing Key Laboratory of New Drug Mechanism and Pharmacological Evaluation Study,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)
出处
《药学学报》
CAS
CSCD
北大核心
2020年第3期421-426,共6页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(81773715)
国家科技重大新药创制专项(2018ZX09711001-001-012).
关键词
睡眠
觉醒
一氧化氮
上行网状激活系统
sleep
arousal
nitric oxide
ascending reticular activating system
作者简介
通讯作者:张建军,Tel:86-10-63182392,E-mail:jjzhang@imm.ac.cn
