摘要
目的探讨新疆地区丙型肝炎病毒基因型特点、基因型与丙型肝炎进展的关系。方法选取2018年1—12月新疆维吾尔自治区人民医院收治的469例丙型肝炎患者,采集静脉血,检测抗丙型肝炎病毒(HCV)抗体、HCV-RNA、HCV基因分型、血红蛋白(Hb)、血小板(PLT)、丙氨酸氨基转移酶(ALT)、谷丙氨酸转氨酶(AST)、血清胆碱酯酶(ChE)、总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)、γ谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)等指标,根据不同基因型分组并进行比较。结果469名患者血样中共检出1b型249例(53.1%),2a型113例(24.1%),3a型67例(14.3%)、3b型37例(7.9%)、6a型3例(0.6%)。不同基因型组患者年龄、性别比较,差异有统计学意义(P<0.05)。基因1b型患者PLT水平低于其他基因型,ALT、AST、GGT水平均高于其他基因型组,差异有统计学意义(P<0.05)。基因1b型患者HCV-RNA水平高于其他基因型,差异有统计学意义(P<0.05)。不同基因型慢性丙型病毒性肝炎、丙型肝炎后肝纤维化、丙型肝炎后肝硬化代偿期发生率比较,差异均有统计学意义(P<0.05)。结论新疆地区丙型肝炎患者以1b型为主,1b型HCV感染患者与其他基因型感染者比较其PLT计数较低,肝细胞受损较其他基因型患者严重,1b型HCV感染患者HCV-RNA载量高于其他基因型,1b型HCV感染患者相对于其他基因型感染更易发展为肝纤维化、肝硬化。
Objective To investigate the relationship between genotyping characteristics of hepatitis C virus and the progress of hepatitis C disease in Xinjiang.Methods From January 1,2018 to December 31,2018,469 patients with hepatitis C treated in Xinjiang Uygur Autonomous Region People’s Hospital were enrolled in this study.Venous blood was collected to detect anti-HCV antibody test,HCV-RNA,HCV genotyping,and hemoglobin(Hb),platelets(PLT),alanine aminotransferase(ALT),aspartate aminotransferase(AST),serum cholinesterase(ChE),total bilirubin(TBIL),direct bilirubin(DBIL),indirect bilirubin(IBIL),γ-glutamyl transpeptidase(GGT),alkaline phosphatase(ALP).Clinical data,blood indicators and disease progressionwere compared among different groupswith different genotypes.Results A total of 5 genotypes were detected in 496 patients’blood samples,of which 249 patients(53.1%)with type 1 b,113 patients(24.1%)with type 2 a,67 patients(14.3%)with type 3 a,37 patients(7.9%)with type 3 b and 3 patients(0.6%)with type 6 a.There were significant differences in age and sex among different genotype groups(P<0.05).PLT count of type 1 b group was lower than those of other genotype groups,and the levels of ALT,AST,GGT,and HCV-RNA of type 1 b group were higher than those of other genotype groups.The level of HCV-RNA in type 1 b group was higher than those in other genotype group,and the difference was statistically significant(P<0.05).There were significant differences in proportions of hepatitis C,liver fibrosis,and compensated cirrhosis among different genotypes(P<0.05).Conclusion Hepatitis C patients in Xinjiang are mainly type 1 b.In type 1 b HCV infected patients,the PLT count is lower,the liver cell damage is more serious,the HCV-RNA load is higher,and the patients are more likely to develop liver fibrosis and cirrhosis.
作者
依力哈木·阿不力提甫
文倩
张永萍
YILIHAMU Abulitifu;WENG Qian;ZHANG Yong-ping(Xinjiang Uygur Autonomous Region People’s Hospital,Urumqi 830000,China)
出处
《慢性病学杂志》
2020年第5期670-673,共4页
Chronic Pathematology Journal
关键词
新疆
丙型肝炎
基因型
肝炎病毒
Xinjiang
Hepatitis C
Genotyping
Hepatitis virus
作者简介
依力哈木·阿不力提甫,硕士,住院医师,研究方向:丙型病毒性肝炎的临床特点及预后相关研究;通信作者:张永萍,E-mail:13999233386@163.com
