摘要
目的探讨阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)患者尿酸水平与颈动脉内膜中层厚度(carotid intima-media thickness,CIMT)的关系。方法选取2020年1月-2021年8月在十堰市人民医院行多导睡眠检测(polysomnography,PSG)的116例患者作为研究对象,所有患者均行颈动脉超声检查。依据呼吸暂停低通气指数(apnea-hypopnea index,AHI)分为OSAHS组(101例)和对照组(15例),OSAHS组进一步分为轻、中、重度OSAHS组;比较两组患者CIMI情况、传统危险因素及血脂、肾功能等指标。采用Pearson相关性分析评估尿酸与颈动脉内膜增厚的相关性。结果对照组与OSAHS组AHI、最低血氧饱和度(lowest SaO_(2),LSaO_(2))、尿酸、体质量指数(body mass index,BMI)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、CIMT比较,差异有统计学意义(P<0.05);轻、中、重度OSAHS组AHI、BMI、尿酸、CIMT比较,差异有统计学意义(P<0.05)。Pearson相关分析结果显示,CIMT与尿酸及AHI成正相关,差异有统计学意义(r值分别为0.608、0.312,P<0.05)。结论OSAHS患者尿酸水平随着OSAHS严重程度加重而升高,且尿酸水平与CIMT成正相关,应加强对OSAHS患者的尿酸监测,并适时干预。
Objective To determine the association between uric acid levels and carotid intima-media thickness(CIMT)in patients with obstructive sleep-apnoea hypopnea syndrome(OSAHS).Methods One hundred and sixteen patients who underwent polysomnography at the Shiyan Renmin Hospital from January2020 to August 2021 were selected.Carotid artery ultrasonography was performed on all patients.Patients were divided into OSAHS and control groups based on the apnea-hypopnea index(AHI).The OSAHS group was further divided into mild,moderate,and severe OSAHS groups.The CIMT,traditional risk factors,blood lipid,and renal function were compared between the two groups.Pearson analysis was used to determine the relationship between the uric acid level and CIMT.Results The following were significantly different between the OSAHS and control groups:AHI;lowest SaO_(2);uric acid level;body mass index(BMI);and low-density lipoprotein-cholesterol concentration.There was a statistically significant difference in AHI,BMI,uric acid level,and CIMT among patients with mild,moderate,and severe OSAHS(P<0.05).Pearson analysis demonstrated that CIMT was positively associated with the uric acid level and AHI(r=0.608,0.312,all P<0.05).Conclusions As the uric acid level increases,the severity of OSAHS increases and correlates with CIMT thickening.The serum uric acid level should be monitored in OSAHS patients to guide intervention in a timely fashion.
作者
周梦阁
陈光辉
ZHOU Mengge;CHEN Guanghui(Postgraduate Training Base of Jinzhou Medical University,Department of Neurology,Renmin Hospital,Shiyan,Hubei 442000,China;不详)
出处
《慢性病学杂志》
2023年第1期31-33,共3页
Chronic Pathematology Journal
作者简介
周梦阁,硕士研究生在读,研究方向:脑血管病;通信作者:陈光辉,E-mail:chenguanghui-1999@163.com
