摘要
目的探讨贝伐单抗联合奥沙利铂治疗胃癌的效果。方法选取2016年1月至2018年12月间南京梅山医院收治的96例胃癌患者,根据采用的治疗方法不同进行分组,其中,采用贝伐单抗治疗的48例患者纳入对照组,在贝伐单抗基础上联合奥沙利铂治疗的48例患者纳入研究组。比较两组患者的疗效评、免疫指标、生活质量评分及不良反应发生率。结果研究组临床治疗有效率为93.8%,高于对照组的79.2%,差异有统计学意义(P<0.05)。治疗前,两组患者免疫指标比较,差异无统计学意义(P>0.05)。治疗后,研究组免疫指标水平均高于对照组,差异均有统计学意义(均P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。研究组生活质量各项评分均高于对照组,差异均有统计学意义(均P<0.05)。结论对胃癌患者进行贝伐单抗联合奥沙利铂治疗,效果理想,可降低患者各免疫指标水平,对患者生活质量提升具有很好促进作用,能降低不良反应发生率。
Objective To investigate the efficacy of bevacizumab combined with oxaliplatin for gastric cancer.Methods A total of 96 patients with gastric cancer treated at Nanjing Meishan Hospital from January 2016 to December 2018 were selected and randomly divided into a study group and a control group with 48 patients in each group.The study group was treated with bevacizumab combined with oxaliplatin and the control group was only treated with bevacizumab.Efficacy,immunity indicators,quality of life and incidence of adverse reactions was compared between the two groups.Results The efficacy rate of treatment was 93.8%in the study group which was higher than 79.2%of the control group(P<0.05).There was no significant difference in immune indicators between the two groups before the treatment(P>0.05).After the treatment,the immune indicators were higher in the study group than in the control group(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The scores of quality of life were higher in the study group was than in the control group(all P<0.05).Conclusion Bevacizumab combined with oxaliplatin shows an ideal efficacy,which can improve the levels of immune indicators as well as quality of life and reduce the incidence of adverse reactions in patients with gastric cancer.
作者
李丹
文亢
高金宝
LI Dan;WEN Kang;GAO Jin-bao(Department of Pharmacy,Nanjing Meishan Hospital,Nanjing 210041,China;Department of Oncology,Nanjing Meishan Hospital,Nanjing 210041,China)
出处
《中国肿瘤临床与康复》
2020年第3期331-334,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
贝伐单抗
奥沙利铂
胃肿瘤
不良反应
生活质量
免疫功能
Bevacizumab
Oxaliplatin
Gastric neoplasms
Adverse reactions
Quality of life
Immune function
作者简介
李丹,女,主管药师,主要从事临床药学专业;通信作者:高金宝,Email:susanlidan@126.com
