摘要
Piezo1通道是能够感受剪切力、张力、扭转等一系列机械刺激,将机械信号转化成生物电信号的一种机械敏感性离子通道,在血管的形成与发展、血管的收缩与舒张、动脉瓣和静脉瓣的形成、血压调控和红细胞体积稳态中扮演重要角色,与心血管系统关系密切。近年研究表明中药复方及其有效成分可通过干预Piezo1通道,影响Ca^(2+)内流、内皮细胞及血小板功能,进而调节血栓形成与内皮稳态,治疗心血管疾病。该文主要综述Piezo1通道在心血管疾病中的作用以及中医药基于Piezo1通道防治心血管疾病的研究进展,以期为Piezo1通道在中医药领域的进一步研究提供参考。
Piezo1 channel is a mechanosensitive ion channel that opens in response to shear stress, tension, torsion and a series of mechanical stimulation and turns them into biological signals. It plays an important role in vascular development, vasoconstriction and vasodilation, formation of arterial and venous valves, blood pressure regulation and red blood cell homeostasis, and thus is closely related to cardiovascular system. Recent studies have shown that traditional Chinese medicine(TCM) compounds and their active components can affect Ca^(2+)influx and endothelial cell and platelet function by mediating Piezo1 channel, and regulate thrombosis and endothelial homeostasis, thereby treating cardiovascular diseases. This study mainly reviewed the role of Piezo1 channel in cardiovascular diseases and the prevention and treatment of cardiovascular diseases based on Piezo1 channel in TCM, in order to provide effective reference for the further research of Piezo1 channel in the field of TCM.
作者
杨丽丽
康静
刘建勋
李磊
YANG Li-li;KANG Jing;LIU Jian-xun;LI Lei(National Clinical Research Center for Chinese Medicine Cardiology,Beijing Key Laboratory of Pharmacology of Chinese Materia Medica,Institute of Basic Medical Sciences of Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China;Heilongjiang University of Chinese Medicine,Harbin 150040,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2022年第24期6533-6540,共8页
China Journal of Chinese Materia Medica
基金
国家自然科学基金面上项目(82174015)
中国中医科学院科技创新工程项目(CI2021A04609)
关键词
Piezo1
机械敏感性离子通道
心血管疾病
中医药
综述
Piezo1
mechanosensitive ion channel
cardiovascular disease
traditional Chinese medicine
review
作者简介
杨丽丽,硕士研究生,E-mail:18997762675@163.com;通信作者:李磊,副研究员,Tel:(010)62835608,E-mail:lilei0502@126.com
