摘要
目的对血液透析尿毒症患者CRP,IL-2和TNF-α水平进行研究。方法选取2017年04月至2018年04月我院泌尿科96例持续血液净化与透析并伴随医院感染的尿毒症患者(观察组),再选取同期健康受检者96例(对照组),观察组接受持续高通量血液透析治疗,对照组不接受治疗。通过酶联反应检测观察组治疗前后血清炎症因子水平,并探讨血清C反应蛋白(CRP)、白细胞介素-2(IL-2)、肿瘤坏死因子-α(TNF-α)水平的相关性与尿毒症患者之间的关联性。结果相较于治疗前,观察组治疗后IL-2、CRP及TNF-α水平明显更低,差异有统计学意义(P<0.05)。两组治疗后IL-2、CRP及TNF-α水平差异无统计学意义(P>0.05)。观察组CRP表达与IL-2、TNF-α表达具有正相关性(P<0.05)。结论持续血液净化与透析并伴随医院感染的尿毒症患者存在血清炎症情况,可通过持续高通量血液透析降低患者血清炎症因子水平,使血清炎症得到有效改善。
Objective To study the levels of CRP,IL-2 and TNF-αin hemodialysis patients with uremia.Methods From April 2017 to April 2018,96 uremic patients(observation group)with continuous blood purification and dialysis and hospital infection were selected from the urology department of our hospital,and then 96 healthy subjects(control group)were selected from the same period.The observation group received continuous high-throughput hemodialysis treatment,while the control group did not receive treatment.The levels of serum inflammatory factors in the observation group before and after treatment were detected by enzyme-linked reaction,and the correlation between the levels of serum C-reactive protein(CRP),interleukin-2(IL-2),tumor necrosis factor-α(TNF-α)and uremic patients was studied.Results Compared with before treatment,the levels of IL-2,CRP and TNF-αin the observation group were significantly lower after treatment(P<0.05).There was no significant difference in the levels of IL-2,CRP and TNF-αbetween the two groups(P>0.05).The expression of CRP was positively correlated with the expression of IL-2 and TNF-αin the observation group(P<0.05).Conclusion There is serum inflammation in uremic patients with continuous blood purification and dialysis accompanied by hospital infection,which can be effectively improved by reducing the level of serum inflammatory factors through continuous high-throughput hemodialysis.
作者
刘春玲
陈亮
李明风
LIU Chun-ling;CHEN Liang;LI Ming-feng(Department of laboratory,Enping people’s Hospital,Enping,Guangdong 529400;Inspection center of disease control and prevention center of Enping,Enping,Guangdong 529400;Department of laboratory,Enping maternal and child health hospital,Enping,Guangdong 529400)
出处
《智慧健康》
2020年第8期108-110,共3页
Smart Healthcare
基金
江门市科技计划项目名称:血液透析尿毒症患者CRP,IL-2和TNF-α水平的研究。项目编号:2018L002
作者简介
刘春玲(1981-),女,广东潮安,汉族,主管检验师,本科,研究方向:临床医学检验;陈亮(1982-),男,湖南双峰人,副主任技师,大学本科,研究方向:临床医学检验;李明风(1979-),男,广东徐闻,主管检验技师,大学本科,研究方向:临床医学检验。
