摘要
目的分析不同产前诊断指征的羊水细胞染色体核型。方法选取我院自2019年11月至2020年1月收治的360例具有产前诊断指征并采用羊水穿刺行羊水细胞染色体核型分析的患者,并对产前诊断指征的不同对染色体异常的预测价值进行分析。结果针对360例患者进行产前诊断,在羊水标本中共检出染色体异常核型346例,其中T21患者131例、占总数的37.86%,T18患者82例、占总数的23.70%,T13患者41例、占总数的11.85%,性染色体异常患者45例、占总数的13.01%,易位28例、占总数的8.09%,嵌合体12例、占总数的3.47%,其他7例、占总数的2.02%;在346例染色体异常核型中,常染色体数目异常261例、性染色体异常45例、平衡性结构异常26例、嵌合体12例、倒位2例。结论采用羊水细胞染色体核型分析能有效提高胎儿染色体病的诊断准确率,减少染色体异常胎儿的出生,为我国人口质量的提高有着极为重要的帮助,值得广泛推广使用。
Objective To analyze the karyotype of amniotic fluid cells with different prenatal diagnosis indications.Methods A total of 360 patients with prenatal diagnosis indications and chromosome karyotype analysis of amniotic fluid cells treated with amniotic fluid puncture were selected from our hospital from November 2019 to January 2020.Analysis of the predictive value.Results A total of 346 chromosomal abnormal karyotypes were detected in amniotic fluid samples from 360 patients.Among them,131 patients were T21 patients,accounting for 37.86%of the total,82 patients were T18 patients,accounting for 23.70%,and T13 patients were 41 patients.Accounting for 11.85%of the total,45 patients with sexual chromosomal abnormalities,13.01%of the total,28 translocations,8.09%of the total,12 chimeras,3.47%of the total,and 7 other,2.02%of the total.Among 346 cases of abnormal karyotypes,261 were abnormal in the number of autosomal chromosomes,45 in the sex chromosome,26 in the balance structure,12 in the chimera and 2 in the inversion.Conclusion The use of karyotype analysis of amniotic fluid cells can effectively improve the diagnostic accuracy of fetal chromosome disease and reduce the birth of chromosomal abnormal fetuses.It has extremely important help for the improvement of the quality of our population and is worthy of widespread use.
作者
秦昌红
QIN Chang-hong(Linyi Maternal and Child Health Hospital,Linyi,Shandong 276000)
出处
《智慧健康》
2020年第14期57-59,共3页
Smart Healthcare
关键词
产前诊断指征
羊水细胞染色体
核型分析
Prenatal diagnosis indication
Amniotic fluid cell chromosome
Karyotype analysis
