摘要
目的研究肠内营养支持对肝硬化失代偿期患者肝功能、血清蛋白及炎症因子的影响。方法选取2016年3月至2019年3月58例肝硬化失代偿期患者作为研究样本,采用随机双盲法分别纳入参照组(29例,接受常规饮食)和研究组(29例,接受肠内营养支持),统计、比较两组患者治疗前后的肝功能各指标水平、各蛋白指标水平以及炎症因子水平情况。结果治疗前,两组肝功能ALT、AST、TBIL、PT各指标水平、血清总蛋白、血清白蛋白、血清球蛋白以及前白蛋白水平、CRP、IL-6以及TNF-α炎症因子水平差异无统计学意义,(P>0.05);治疗后,研究组肝功能ALT、AST、TBIL、PT各指标水平、血清总蛋白、血清白蛋白、血清球蛋白以及前白蛋白水平、CRP、IL-6以及TNF-α炎症因子水平均优于参照组,差异有统计学意义(P<0.05)。结论在常规治疗的同时,对肝硬化失代偿期患者再予以肠内营养支持,可以有效改善患者的肝功能和营养状况,利于患者免疫功能的增强。
Objective To study effect of enteral nutrition on liver function,serum protein and inflammatory factors of decompensated cirrhosis patients.Methods The paper chose 58 cases decompensated liver cirrhosis patients from March 2016 to March 2019 as research samples,and divided them into reference group(29 cases,with routine diet)and study group(29 cases,with enteral nutrition support)with double-blind method randomly.Levels of liver function indexes,protein indexes and inflammatory factors between two groups before and after treatment were statistically compared.Results Before treatment,levels of ALT,AST,TBIL,PT,serum total protein,serum albumin,serum globulin,prealbumin,CRP,IL-6 and TNF-αshowed no significant difference between two groups,(P>0.05);after treatment,levels of ALT,AST,TBIL,PT,serum total protein,serum albumin,serum globulin and prealbumin,CRP,IL-6 and TNF-αin study group were significantly higher than control group(P<0.05).Conclusion During routine treatment,enteral nutrition support can improve liver function and nutritional status of decompensated cirrhosis patients effectively,which is conducive to enhancement of immune function.
作者
刘先秒
郑振
邓志明
张艳华
LIU Xian-miao;ZHENG Zhen;DENG Zhi-ming;ZHANG Yan-hua(People's Hospital of Gaoyao District,Zhaoqing City,Zhaoqing,Guangdong,526000)
出处
《智慧健康》
2021年第21期1-4,共4页
Smart Healthcare
关键词
肠内营养
肝硬化
肝功能
血清蛋白
炎症因子
Enteral nutrition
Cirrhosis
Liver function
Serum albumin
Inflammatory factors
