摘要
目的分析五种血清肿瘤标志物在肺癌患者诊断中的优势和准确性。方法将本院自2019年1月-2020年12月接收治疗的50名肺癌患者作为观察组研究对象,另将同一时期的50名健康志愿者作为本次对照组研究对象,分析两组人群在进行肿瘤标志物检查后的CEA、Pro-GRP、SCCA、CA211、CA125水平变化。对比分析血清肿瘤标志物的灵敏度、特异度和准确度。结果与对照组患者相比较,观察组患者CEA、Pro-GRP、SCCA、CA211、CA125水平明显更高,而观察组内小细胞癌患者Pro-GRP水平明显更高于鳞癌与腺癌患者、鳞癌患者SCCA水平明显更高于小细胞癌与腺癌患者,对比统计学差异明显(P<0.05),其余水平组内对比并无显著差异(P>0.05);研究可见,CEA、Pro-GRP、SCCA、CA211、CA125的灵敏度分别为30.0%、30.0%、30.0%、50.0%、40.0%,联合诊断为90.0%;特异度为90.0%、92.0%、96.0%、90.0%、90.0%,联合诊断为96.0%;准确度为70.0%、60.0%、60.0%、70.0%、90.0%,联合诊断为90.0%。结论在疑似肺癌患者的临床诊断中对患者采用CEA、Pro-GRP、SCCA、CA211、CA125等血清标志物进行检查具有灵敏度、特异度以及准确度高等优势,将多种血清肿瘤标志物联合检测可明显提高疾病诊断灵敏度和准确度,值得临床广泛应用。
Objective Analyze the advantages and accuracy of five serum tumor markers in the diagnosis of lung cancer patients.Methods Fifty lung cancer patients who received treatment in our hospital from January 2019 to December 2020 were taken as the observation group research subjects,and 50 healthy volunteers during the same period were used as the control group research subjects.The changes in the levels of CEA,Pro-GRP,SCCA,CA211 and CA125 in the group population after tumor marker examination.Comparative analysis of the sensitivity,specificity and accuracy of serum tumor markers.Results Compared with the control group,the observation group had significantly higher levels of CEA,Pro-GRP,SCCA,CA211 and CA125.While the small cell carcinoma patients in the observation group had significantly higher Pro-GRP levels than squamous cell carcinoma and adenocarcinoma patients.The level of SCCA in patients with squamous cell carcinoma was significantly higher than that in patients with small cell carcinoma and adenocarcinoma,and the difference was statistically significant(P<0.05).There was no significant difference in the other levels within the group(P>0.05).The study showed that the sensitivity of CEA,Pro-GRP,SCCA,CA211,CA125 were 30.0%,30.0%,30.0%,50.0%,40.0%,combined diagnosis was 90.0%.The specificity was 90.0%,92.0%,96.0%,90.0%,90.0%,the combined diagnosis is 96.0%.The accuracy is 70.0%,60.0%,60.0%,70.0%,90.0%,and the combined diagnosis is 90.0%.Conclusion In the clinical diagnosis of suspected lung cancer patients,CEA,pro-GRP,SCCA,CA211,CA125 and other serum markers have the advantages of high sensitivity,specificity and accuracy.Combined detection of multiple serum tumor markers can significantly improve the sensitivity and accuracy of disease diagnosis,which is worthy of wide clinical application.
作者
张先娥
ZHANG Xian-e(General Hospital of Xuzhou Mining Group,Xuzhou,Jiangsu 221000)
出处
《智慧健康》
2021年第34期1-3,共3页
Smart Healthcare
关键词
血清
肿瘤标志物
肺癌
诊断优势
准确性
Serum
Tumor markers
Lung cancer
Diagnostic advantage
Accuracy
