摘要
目的探讨白介素6(IL-6)联合降钙素原(PCT)检测对评估重型颅脑外伤(STBI)患者预后的价值分析。方法纳入2018年3月-2020年3月我院收治的60例重型颅脑损伤患者的一般资料做回顾性分析,以28d死亡与否进行分组和对照组,各30例。28d死亡的患者作为对照组,未死亡的患者作为研究组。分别采集两组患者的一般资料,留存血液样本用于检测IL-6及PCT水平,对比两组患者入院1d、3d后IL-6、PCT水平、颅内压变化及一般生命体征差异。结果入院1d,两组患者PCT、IL-6水平无显著差异(P>0.05);入院3d,研究组患者PCT、IL-6水平显著低于对照组(P<0.05);两组患者入院1d颅内压对比无显著差异(P>0.05);入院3d,研究组患者的颅内压明显低于对照组(P<0.05);研究组患者体温水平明显高于对照组,心率及呼吸水平显著低于对照组(P<0.05)。结论PCT是STBI病情评估的特异性指标,IL-6水平也可一定程度地反映出颅脑外伤的严重程度,两项指标联合检测可显著提高对STBI患者预后病情评估的准确度和灵敏度,值得推广。
Objective To explore the value of interleukin-6(IL-6)combined with procalcitonin(PCT)in evaluating the prognosis of patients with severe craniocerebral trauma.Methods A total of 60 patients with severe craniocerebral injury who were admitted to our hospital from March 2018 to March 2020 were included in the retrospective analysis of the general data,and they were divided into a death group(28 days old)and a control group(30 cases in each group).Patients who died within 28 days were used as the control group and those who did not die were used as the study group.General data of two groups were collected,and blood samples were retained for the detection of IL-6 and PCT levels.IL-6 and PCT levels,intracranial pressure changes and general vital signs differences between the two groups one day and three days after admission were compared.Results One day after admission,there was no significant difference in PCT and IL-6 levels between the two groups(P>0.05).Three days after admission,the levels of PCT and IL-6 in the research group were significantly lower than those in the control group(P<0.05).There was no significant difference in intracranial pressure on day 1 of admission between the two groups(P>0.05).Three days after admission,the intracranial pressure of the patients in the study group was significantly lower than that in the control group(P<0.05).The body temperature of the patients in the research group was significantly higher than that in the control group,and the heart rate and respiratory rate were significantly lower than those in the control group(P<0.05).Conclusion PCT is a specific indicator for the assessment of severe craniocerebral trauma,and IL-6 level can also reflect the severity of craniocerebral trauma to a certain extent.The combined detection of the two indicators can significantly improve the accuracy and sensitivity of the assessment of the prognosis and condition of patients with severe craniocerebral trauma,and is worthy of promotion.
作者
梁健欣
LIANG Jianxin(Emergency Department,Shantou Central Hospital,Shantou,Guangdong 515000)
出处
《智慧健康》
2022年第2期10-12,共3页
Smart Healthcare
关键词
重型颅脑外伤
降钙素原
白介素6
预后评估
Severe craniocerebral trauma
Procalcitonin
Interleukin 6
Prognostic assessment
