摘要
目的探讨普萘洛尔联合奥美拉唑在肝硬化并胃溃疡治疗中的应用效果及其安全性。方法本研究84例肝硬化并胃溃疡患者均为甘肃省兰州市城关区人民医院2018年5月-2019年12月接收,基于随机数字表法分组,采取奥美拉唑与维生素B6治疗者为对照组(42例),实施普萘洛尔联合奥美拉唑治疗者为观察组(42例),对治疗效果、不良反应发生状况、临床指标等进行对比分析。结果治疗总有效率方面,观察组(92.86%)比对照组(76.19%)高,差异明显(P<0.05);住院时间、胃溃疡达到H期时间、反酸消失时间、腹胀腹痛消失时间方面,观察组均比对照组短,差异显著(P<0.05);不良反应发生率方面,观察组(4.76%)与对照组(7.14%)相比,无明显差异(P>0.05)。嗳气吞酸、胃部疼痛及胸肋胀满评分方面,治疗前两组差异较小(P>0.05),观察组治疗后较对照组低(P<0.05)。生存质量评分(社会功能、躯体疼痛、生理功能、情感职能)方面,观察组比对照组高,差异明显(P<0.05)。结论肝硬化合并胃溃疡临床治疗过程中,联合普萘洛尔与奥美拉唑,不仅可以减轻腹痛、反酸等临床症状,提高治疗效果,而且安全性高,此外有助于患者生存质量提高,值得采纳与推广。
Objective To investigate effect and safety of propranolol combined with omeprazole in treatment of liver cirrhosis with gastric ulcer.Methods The paper chose 84 patients with liver cirrhosis and gastric ulcer in Lanzhou City Chengguan District People’s Hospital from May 2018 to December 2019.Based on random number table method,patients treated with omeprazole and vitamin B6 were included in control group(42 cases),and patients with propranolol and omeprazole in observation group(42 cases).Treatment effect,adverse reactions and clinical indicators were compared and analyzed.Results Total effective rate of observation group(92.86%)was higher than control group(76.19%)(P<0.05);length of stay,time of gastric ulcer reaching stage H,time of acid regurgitation disappearance,time of abdominal distension and abdominal pain disappearance in observation group was significantly shorter than control group(P<0.05);Incidence of adverse reactions showed no significant difference between observation group(4.76%)and control group(7.14%)(P>0.05).There was little difference between two groups before treatment in scores of belching,acid swallowing,stomach pains and chest and rib fullness,(P>0.05);After treatment,that of observation group was lower than control group(P<0.05).Life quality scores(social function,physical pain,physiological function,emotional function)of observation group were higher than control group(P<0.05).Conclusion Combination of propranolol and omeprazole can reduce clinical symptoms of abdominal pain and acid regurgitation in clinical treatment of liver cirrhosis with gastric ulcer,improve treatment effect with high safety.in addition,it can improve life quality of patients,which is worthy of application and promotion.
作者
雷小刚
张瑞祯
何述虎
LEI Xiaogang;ZHANG Ruizhen;HE Shuhu(Lanzhou City Chengguan District People's Hospital,Lanzhou,Gansu,730030)
出处
《智慧健康》
2022年第27期88-92,共5页
Smart Healthcare
关键词
肝硬化
胃溃疡
普萘洛尔
奥美拉唑
不良反应
Liver cirrhosis
Gastric ulcer
Propranolol
Omeprazole
Adverse reactions
