摘要
目的观察还原离子疗法干预代谢综合征患者的临床疗效。方法将80例代谢综合征患者按照随机数字表分为对照组(n=40)和试验组(n=40)。对照组患者给予常规治疗,试验组在对照组基础上给予还原离子疗法治疗,4周为疗程,连续用药2个疗程。观察并比较血压、腹围、BMI、胰岛素抵抗、糖脂代谢指标、肾脏损害指标变化,监测血清中脂联素(Adiponectin,ADPN)含量。结果治疗后,观察组患者的血压、腹围、BMI、胰岛素抵抗情况、糖脂代谢改善更明显,血压、腹围、BMI均较对照组明显降低(P<0.05),FINS、2hINS、HOMA-IR明显低于对照组,HOMA-β明显高于对照组(P<0.05),FPG、2hPG、HbAlc、TG、TC水平与对照组相比均明显降低,HDL-C水平则明显高于对照组(P<0.05);观察组患者的尿微量白蛋白/肌酐比值显著低于对照组,差异有统计学意义(t=11.457,P<0.05)。结论加用还原离子疗法更利于控制代谢综合征患者的血压,减小的体质量指数、腹围,改善胰岛素抵抗、糖脂代谢,保护肾组织,原因可能与影响脂联素信号通路、减轻氧化应激损伤有关,值得推广。
Objective To observe clinical curative effect of reducing ion therapy for patients with metabolic syndrome.Methods The paper chose 80 patients with metabolic syndrome,and divided them into control group(n=40)and experimental group(n=40)according to random number table.Control group was treated with routine treatment,while experimental group with reduction ion therapy on the basis of control group.Treatment lasted for 4 weeks and was administered continuously for 2 courses.Changes in blood pressure,abdominal circumference,BMI,insulin resistance,glucose and lipid metabolism indicators,and kidney damage indicators,and monitor content of adiponectin(ADPN)in serum were observed and compared.Results After treatment,observation group showed more significant improvements in blood pressure,abdominal circumference,BMI,insulin resistance,and glucose and lipid metabolism.Blood pressure,abdominal circumference,and BMI were significantly lower than control group(P<0.05),while FINS,2hINS,HOMA-IR were significantly lower than control group.Levels of HOMA-β,FPG,2hPG,HbAlc,TG,and TC were significantly lower than control group(P<0.05),while levels of HDL-C were significantly higher than control group(P<0.05).Urinary microalbumin/creatinine ratio(27.52±3.11)mg/g in observation group was significantly lower than(32.45±4.20)mg/g in control group,with statistically significant difference(t=11.457,P<0.05).Conclusion Reducing ion therapy is beneficial for controlling blood pressure of patients with metabolic syndrome,reducing body mass index and abdominal circumference,improving insulin resistance,glucose and lipid metabolism,and protecting renal tissue.The reason may be related to affecting adiponectin signaling pathway and reducing oxidative stress damage,which is worthy of promotion.
作者
郑曼娜
刘玉成
ZHENG Manna;LIU Yucheng(Outpatient Department,Guangzhou Public Security Bureau Comprehensive Security Center,Guangzhou,Guangdong 510036)
出处
《智慧健康》
2023年第10期48-51,共4页
Smart Healthcare
基金
广州市越秀区教育卫生专项项目《还原离子疗法对代谢综合征临床疗效评价及脂联素信号通路的影响研究》(项目编号:2019-WS-004)
关键词
还原离子疗法
代谢综合征
脂联素
Reducing ion therapy
Metabolic syndrome
Adiponectin
作者简介
郑曼娜(1979-),女,汉族,广东潮州,主管技师,本科,研究方向:临床康复。
