摘要
脑胶质瘤是颅内最常见的原发性恶性肿瘤,放化疗是脑胶质瘤综合治疗的重要手段,然而胶质瘤,尤其胶质母细胞瘤是血管化程度最高的恶性肿瘤,肿瘤常处于乏氧状态,放化疗常呈现出抵抗性。探索胶质瘤放化疗敏感性的影响因素及其内在机制,有助于改善胶质瘤患者的预后。本文从胶质瘤缺氧微环境、胶质瘤干细胞及微小RNA等方面阐述了胶质瘤放化疗敏感性的调节机制。
Glioma is the most common primary intracranial malignant tumor,radiotherapy and chemotherapy is an important means of glioma treatment.However,glioma,especially glioblastoma,is the malignant tumor with the highest degree of vascularization,the tumor is often in hypoxia status,and the resistance to chemoradiotherapy is common.The exploration of factors influencing the sensitivity of glioma to chemoradiotherapy and its mechanism is helpful to improve the prognosis of glioma patients.In this article,the regulatory mechanism related to the sensitivity of glioma to chemoradiotherapy was discussed in terms of hypoxic microenvironment,glioma stem cells and miRNA.
作者
钟佳伟
牟福玲
孙鹏飞
ZHONG Jia-wei;MOU Fu-ling;SUN Peng-fei(The Second School of Clinical Medicine,Lanzhou University,Lanzhou 730030,China;Lanzhou University Second Hospital,Lanzhou 730030,China)
出处
《中国肿瘤》
CAS
CSCD
北大核心
2020年第4期299-303,共5页
China Cancer
基金
甘肃省自然科学基金(17JR5RA249)
兰大二院人才引进项目(ldeyrczx201536).
作者简介
通信作者:孙鹏飞,E-mail:ery_sunpf@lzu.edu.cn
