摘要
目的探讨自身免疫性脑炎(AE)患者血清免疫球蛋白水平与其疾病转归的关系。方法选取2019年1月至2022年1月四川大学华西医院收治的95例AE患者设为观察组,另选择60例同期正常体检者设为对照组。比较两组免疫球蛋白水平;比较观察组中不同预后患者免疫球蛋白水平,并分析AE患者疾病转归的影响因素。结果观察组免疫球蛋白IgA、IgM、IgG水平均高于对照组,差异有统计学意义(P<0.05);观察组中预后良好者64例,预后不良者31例;预后良好组IgA、IgM、IgG水平均低于预后不良者,差异有统计学意义(P<0.05);ROC曲线提示血清IgA、IgM、IgG单独检测评估AE患者预后的曲线下面积(AUC)为0.671、0.726、0.835,低于三者联合检测的AUC 0.909(P<0.05);多因素分析提示血清IgA、IgM、IgG水平均为AE患者疾病转归的独立影响因素(P<0.05)。结论AE患者血清IgA、IgM、IgG水平均显著提升,且与患者疾病转归密切相关;同时血清免疫球蛋白水平为AE患者疾病转归的独立影响因素,对其预后评估具有一定参考价值。
Objective To explore the levels of serum immunoglobulins and their relationship with disease outcomes in patients with autoimmune encephalitis(AE).Methods A total of 95 patients with AE admitted to the hospital were enrolled as observation group between January 2019 and January 2022,while 60 healthy controls during the same period were enrolled as control group.The levels of immunoglobulins between the two groups and among patients with different prognosis in observation group were compared.The influencing factors of disease outcomes in AE patients were analyzed.Results The levels of immunoglobulin(Ig)A,IgM and IgG in observation group were higher than those in control group(P<0.05).In observation group,there were 64 cases with good prognosis and 31 cases with poor prognosis.The levels of IgA,IgM and IgG were lower in good prognosis group than poor prognosis group(P<0.05).ROC curves analysis showed that area under the curve(AUC)values of IgA,IgM and IgG for evaluating prognosis of AE patients were 0.671,0.726 and 0.835,lower than that of combined detection(0.909,P<0.05).Multivariate analysis showed that serum IgA,IgM and IgG were independent influencing factors of disease outcomes in AE patients(P<0.05).Conclusion The levels of serum IgA,IgM and IgG significantly increase in AE patients,which are closely related to disease outcomes.Serum immunoglobulins are independent influencing factors of disease outcomes in AE patients,which have certain reference value for prognosis evaluation.
作者
唐姗姗
罗曦
TANG Shanshan;LUO Xi(Department of Neurology,West China Hospital,Sichuan University,Chengdu 610041,China)
出处
《中国实验诊断学》
2023年第9期1030-1033,共4页
Chinese Journal of Laboratory Diagnosis
作者简介
唐姗姗(1988-),女,本科学历,中级职称,主要从事癫痫或自身免疫性脑炎的诊疗工作。
