摘要
目的了解泌尿系统感染细菌的分布特征及耐药性。方法收集2021年1月至12月吉林大学中日联谊医院患者尿培养阳性分离出的1536株细菌,使用WHONET5.6软件,分析细菌的分布特征及其对抗菌药物的耐药情况。结果在所分离的1536株细菌中以革兰阴性菌为主,共1132株(73.7%),革兰阳性菌404株(26.3%)。大肠埃希菌和肺炎克雷伯菌对含β-内酰胺酶抑制剂复方制剂和碳青霉烯类药物耐药率较低。粪肠球菌和屎肠球菌对利奈唑胺及万古霉素耐药率较低。在大肠埃希菌和肺炎克雷伯菌中,女性对抗菌药物的敏感性要大于男性。结论革兰阴性菌是我院尿培养主要的分离细菌,在临床诊疗过程中可根据药敏结果选择合适的抗菌药物,对患者进行有效治疗的同时加强对耐药细菌的防控。
Objective Understand the distribution characteristics and drug resistance of pathogenic bacteria in urinary tract infections.Methods We collected 1536 bacterial strains isolated from positive urine cultures of patients in China-Japan union Hospital of Jilin University from January to December 2021,and analyzed the distribution characteristics of the bacteria and their resistance to antimicrobial drugs using WHONET 5.6 software.Results The 1536 bacterial strains isolated were dominated by Gram-negative bacteria,totaling 1132(73.7%)and Gram-positive bacteria,404(26.3%).Escherichia coli and Klebsiella pneumoniae showed low resistance toβ-lactamase inhibitor-containing combinations and carbapenems.Enterococcus faecalis and Enterococcus faecium had low rates of resistance to linezolid and vancomycin.Among Escherichia coli and Klebsiella pneumoniae,females were more susceptible to antimicrobial drugs than males.Conclusion Gram-negative bacteria are the main bacteria isolated from urine culture in our hospital,and appropriate antimicrobial drugs can be selected according to the results of drug sensitivity in the process of clinical diagnosis and treatment,so that the prevention and control of drug-resistant bacteria can be strengthened at the same time as the effective treatment of patients.
作者
姜钧天
鄢超
郑娅楠
刘豪
徐雪松
JIANG Juntian;YAN Chao;ZHENG Yanan;LIU Hao;XU Xuesong(Department of Clinical Laboratory,China-Japan Union Hospital of Jilin University,Changchun 130033,China)
出处
《中国实验诊断学》
2023年第10期1150-1154,共5页
Chinese Journal of Laboratory Diagnosis
基金
国家科技部科技基础资源专项(2019FY101203)
中科院威高计划([2019]002号)
关键词
尿路感染
细菌
药敏试验
耐药性
urinary tract infection
bacteria
drug sensitivity test
drug resistance
作者简介
通信作者:徐雪松
