摘要
目的探讨泮托拉唑钠联合奥曲肽治疗胰腺癌伴急性胰腺炎患者的效果及预后价值。方法选取2018年5月至2019年10月沈阳市第四人民医院收治的胰腺癌伴急性胰腺炎患者80例作为研究对象,按照随机数字表法分为对照组与观察组,每组40例。两组均给予调节水电解质、禁食、补液等常规治疗,对照组在常规治疗基础上给予泮托拉唑钠治疗,观察组在常规治疗基础上给予泮托拉唑钠联合奥曲肽治疗。控制急性胰腺炎后再给予化疗等方法治疗胰腺癌,比较两组治疗效果。结果观察组总有效率高于对照组(95.00%vs 80.00%),差异有统计学意义(P<0.05)。治疗2个疗程后,两组淀粉酶水平均低于治疗前,且观察组均低于对照组,差异有统计学意义(P<0.05)。治疗2个疗程后,两组白细胞介素6、肿瘤坏死因子α、白细胞介素8均低于治疗前,且观察组均低于对照组,差异有统计学意义(P<0.05)。结论泮托拉唑钠联合奥曲肽治疗胰腺癌伴急性胰腺炎能够显著控制病情,其作用机制可能与控制淀粉酶及炎性因子有关。
Objective To explore the efficacy and prognostic value of pantoprazole sodium combined with octreotide in the treatment of pancreatic cancer complicated with acute pancreatitis.Methods A total of 80 patients with pancreatic cancer and acute pancreatitis admitted to our hospital from May 2018 to October 2019 were selected as study subjects,and they were divided into control group and observation group by random number table method,with 40 cases in each group.All patients in the two groups were given routine treatment,such as regulating water and electrolytes,fasting and rehydration,etc.The control group was given pantoprazole sodium on the basis of routine treatment,while the observation group was given pantoprazole sodium combined with octreotide on the basis of routine treatment.Chemotherapy and other methods were used after the control of pancreatitis in the treatment of pancreatic cancer.The treatment effect of two groups were compared.Results The total effective rate of the observation group was higher than that of the control group(95.00%vs 80.00%),there was statistically significant difference(P<0.05).After 2 courses of treatment,amylase levels in both groups were lower than those before treatment,and the level of observation group was lower than that of the control group.There was statistically significant(P<0.05).The interleukin-6(IL-6),necrotic tumor factor(TNF-α),and interleukin-8(IL-8)in the two groups after 2 courses of treatment were all lower than those before treatment,and levels of observation group were lower than those of control group.The difference was statistically significant(P<0.05).Conclusion Pantoprazole sodium combined with octreotide in the treatment of pancreatic cancer with acute pancreatitis can significantly control the disease,and the mechanism may be related to the control of amylase and inflammatory factors.
作者
张艳晶
杨牧
ZHANG Yan-jing;YANG Mu(Department of Pharmacy,the Fourth People's Hospital of Shenyang,Shenyang110000,China;不详)
出处
《中国误诊学杂志》
CAS
2019年第10期446-448,共3页
Chinese Journal of Misdiagnostics
关键词
胰腺肿瘤
胰腺炎
泮托拉唑钠
奥曲肽
pancreatic neoplasms
pancreatitis
pantoprazole sodium
octreotide
