摘要
目的:研究苗药大黄药的化学成分。方法:采用Sephadex LH-20、Lichroprep RP-18、MCI-gel和高效液相等多种色谱分离方法,采用1H-NMR、13C-NMR等波谱技术并结合参考文献对分离得到的化合物进行结构鉴定。结果:从大黄药中分离得到18个化合物,分别鉴定为:芹菜素(1)、(3R,5S,6E,8S,10E)-3,7,11-trimethyl-1,6,10-dodecatriene-3,5,8-triol(2)、邻苯二甲酸二丁酯(3)、对羟基苯乙酸甲酯(4)、methyl(R)-3-hydroxy-5-phenyl pentanoate(5)、methyl 2-O-feruloyl-3-(3′,4′-dihydroxyphenyl)lactate(6)、methyl isoferuloyl-7-(3,4-dihydroxyphenyl)lactate(7)、咖啡酸甲酯(8)、反式对羟基桂皮酸(9)、原儿茶醛(10)、对羟基苯甲酸(11)、2,6-dihydroxy-2,4-dimethyl-3(2H)-benzofuranone(12)、4-羟基苯乙醇(13)、4-羟基-3-甲氧基苯基乙二醇(14)、2-(3′,4′-二羟苯基)-1,3-胡椒环-5-醛(15)、4-acetonyl-3,5-dimerhoxy-p-quinol(16)、(E)-2-(4-hydroxy-3-methyl-2-butenyl)-hydroquinone(17)、(1′R)-1′-(4-hydroxy-3,5-dimethoxyphenyl)propan-1′-ol 4-O-β-D-glucopyranoside(18)。结论:所有化合物均为首次从该植物中分离得到。
Objective:To study the chemical constituents of Miao herbal medicine Elsholtzia penduliflora.Methods:The chemical constituents of Elsholtzia penduliflora were isolated by several column chromatographic techniques such as Sephadex LH-20、Lichroprep RP-18、MCI-gel、HPLC and others.Their structures were identified by spectrum techniques of NMR combined with references.Results:Eighteen compounds were isolated from Elsholtzia penduliflora and identified as apigenin(1),(3R,5S,6E,8S,10E)-3,7,11-trimethyl-1,6,10-dodecatriene-3,5,8-triol(2),dibutylphthalate(3),p-hydroxyphenylacetic acid methyl ester(4),methyl(R)-3-hydroxy-5-phenyl pentanoate(5),methyl 2-O-feruloyl-3-(3′,4′-dihydroxyphenyl)lactate(6),methyl isoferuloyl-7-(3,4-dihydroxyphenyl)lactate(7),caffeic acid methyl ester(8),trans-p-hydroxycinnamic acid(9),protocatechualdehyde(10),4-hydroxybenzoic acid(11),2,6-dihydroxy-2,4-dimethyl-3(2 H)-benzofuranone(12),4-hydroxyphenethyl alcohol(13),4-hydroxy-3-methoxyphenyl glycol(14),2-(3′,4′-dihydroxyphenyl)-1,3-benzodioxole-5-aldehyde(15),4-acetonyl-3,5-dimerhoxy-p-quinol(16),(E)-2-(4-hydroxy-3-methyl-2-butenyl)-hydroquinone(17),(1′R)-1′-(4-hydroxy-3,5-dimethoxyphenyl)propan-1′-ol 4-O-β-D-glucopyranoside(18).Conclusion:All compounds are isolated from this plant for the first time.
作者
张璐
向伦理
杨琳垚
李蓉涛
钟金栋
ZHANG Lu;XIANG Lun-li;YANG Lin-yao;LI Rong-tao;ZHONG Jin-dong(College of Life Science and Technology,Kunming University of Science and Technology,Kunming 650093,China)
出处
《中药材》
CAS
北大核心
2019年第4期785-789,共5页
Journal of Chinese Medicinal Materials
基金
国家自然科学基金(31660100)
云南省应用基础研究计划面上项目(2017FB034)
云南省人培项目(KKSY201426122).
关键词
香薷属
大黄药
化学成分
Elsholtzia
Elsholtzia penduliflora W.W.Smith
Chemical constituents
作者简介
张璐(1994-),女,在读硕士研究生,专业方向:天然药物化学,E-mail:1187398610@qq.com;通讯作者:钟金栋,E-mail:jindongzhongkm@163.com。
