摘要
目的:研究短穗兔耳草的化学成分。方法:采用各种色谱分离方法及核磁技术对短穗兔耳草50%乙醇提取物进行分离纯化及结构鉴定。结果:从短穗兔耳草中分离得到9个葫芦烷型三萜化合物,分别鉴定为:arveninⅠ(1)、arveninⅢ(2)、arveninⅣ(3)、去乙酰氧葫芦素B-2-O-葡萄糖苷(4)、(20R,22ξ)-2β,16α,20,22,25-pentahydroxy-10α-cucurbita-5,23t-diene-3,11-dione(5)、(2β,3β,9β,10α,16α,20β,24Z)-2-(β-D-glucopyranosyloxy)-3,16,20,26-tetrahydroxy-9-methyl-19-norlanost-5,24-diene-11-one(6)、葫芦素G-2-O-β-D-葡萄糖苷(7)、葫芦素B(8)、葫芦苦素D-2-O-β-D-葡萄糖苷(9)。结论:以上9个化合物均为首次从该植物中分离得到,其中,化合物2~7、9为首次从兔耳草属植物中分离得到。
Objective:To study the chemical constituents of Lagotis brachystachya.Methods:The compounds were isolated and purified from the 50%ethanol extraction of Lagotis brachystachya by various chromatographic separation and nuclear magnetic techniques,their structures were identified.Results:Nine cucurbitane triterpenes compounds were isolated from Lagotis brachystachya and identified as arveninⅠ(1),arveninⅢ(2),arveninⅣ(3),deacetoxycucurbitacin B-2-O-glucoside(4),(20R,22ξ)-2β,16α,20,22,25-pentahydroxy-10α-cucurbita-5,23 t-diene-3,11-dione(5),(2β,3β,9β,10α,16α,20β,24Z)-2-(β-D-glucopyranosyloxy)-3,16,20,26-tetrahydroxy-9-methyl-19-norlanost-5,24-diene-11-one(6),cucurbitacin G-2-O-β-D-glucopyranoside(7),cucurbitacin B(8),hexanorcucurbitacin D-2-O-β-D-glucopyranoside(9),respectively.Conclusion:Compounds 1 to 9 are isolated from Lagotis brachystachya for the first time.Among thrm,compounds 2 to 7,9 are isolated from Lagotis genus for the first time.
作者
朱继孝
欧阳香
张红阳
史亚夫
李敏
杜小浪
王洪玲
ZHU Ji-xiao;OUYANG Xiang;ZHANG Hong-yang;SHI Ya-fu;LI Min;DU Xiao-lang;WANG Hong-ling(Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China)
出处
《中药材》
CAS
北大核心
2020年第5期1123-1126,共4页
Journal of Chinese Medicinal Materials
基金
国家自然科学基金项目(81660702,31660098)
江西省自然科学基金项目(20192BAB205104)
“江西民族药现代科技与产业发展协同创新中心”开放基金项目(JXXT2017004)
关键词
短穗兔耳草
化学成分
葫芦烷型三萜
Lagotis brachystachya Maxim.
Chemical constituents
Cucurbitane triterpenes
作者简介
朱继孝(1981-),男,博士,副教授,研究方向:中药与民族药有效成分与作用机制,Tel:0791-87119065,E-mail:zhujx81@sina.com;通讯作者:王洪玲,E-mail:centurymaomao2008@163.com