摘要
目的:研究有柄石韦的化学成分。方法:利用硅胶、Sephadex LH-20葡聚糖凝胶、RP-C_(18)、PHPLC等柱色谱对有柄石韦进行分离纯化,利用波谱技术对化合物进行结构鉴定。结果:从有柄石韦乙酸乙酯部位分离得到15个化合物,分别鉴别为:对羟基苯丙酸甲酯(1)、6-O-[(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl]-β-D-fructofuranosyl-α-D-glucopyranoside(2)、6′-O-亚油基蔗糖(3)、(2S)-2,3-O-双十八烷-9Z,12Z,15Z-三烯酰基甘油酯-6′-O-(α-D-吡喃半乳糖基)-β-D-吡喃半乳糖苷(4)、山柰酚-7-O-β-D-芹菜苷(5)、开环异落叶松脂醇(6)、异落叶松脂醇(7)、柚皮素-7-O-β-D-葡萄糖醛酸(8)、圣草酚-7-O-β-D-葡萄糖醛酸(9)、4,5-二咖啡酰基奎宁酸甲酯(10)、3,4-O-二咖啡酰基奎尼酸(11)、1,2-二咖啡酰-环戊基-3-醇(12)、没食子酸(13)、香草酸-4-O-β-D-吡喃葡萄糖苷(14)、新绿原酸甲酯(15)。结论:其中,化合物1~8、10、12~15为首次从有柄石韦中分离得到。
Objective:To study the chemical constituents of Pyrrosia petiolosa.Methods:The compounds were isolated and purified by column chromatography,including silica gel,Sephadex LH-20,RP-C_(18)and PHPLC.The structures of obtained compounds were identified by spectroscopy technology.Results:Fifteen compounds were isolated from ethyl acetate extract of Pyrrosia petiolosa and identified as methyl p-hydroxyphenylpropionate(1),6-O-[(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl]-β-D-fructofuranosyl-α-D-glucopyranoside(2),6′-O-linoleylsucrose(3),(2S)-2,3-O-dioctadeca-9Z,12Z,15Z-trienoylglyceryl-6′-O-(α-D-galactopyranosyl)-β-D-galactopyranoside(4),kaempferol-7-O-β-D-apioside(5),secoisolariciresinol(6),(+)-isolariciresinol(7),naringenin-7-O-β-D-glucuronide(8),eriodictyol-7-O-β-D-glucuronide(9),4,5-dicaffeoylquinic acid methyl ester(10),3,4-di-O-caffeoylquinic acid(11),1,2-O-dicaffeoyl-cychopenta-3-ol(12),gallic acid(13),vanillin acid-4-O-β-D-glucopyranoside(14),neochlorogenic acid methyl ester(15),respectively.Conclusion:Among them,compounds 1 to 8,10,12 to 15 are isolated from Pyrrosia petiolosa for the first time.
作者
欧阳兰
周雷罡
周国平
熊晓丽
袁铭铭
OUYANG Lan;ZHOU Lei-gang;ZHOU Guo-ping;XIONG Xiao-li;YUAN Ming-ming(Nanchang University,Nanchang 330006,China;Jiangxi Institute for Drug Control,NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine,Jiangxi Province Engineering Research Center of Drug and Medical Device Quality,Nanchang 330029,China)
出处
《中药材》
CAS
北大核心
2021年第8期1884-1888,共5页
Journal of Chinese Medicinal Materials
基金
江西省重点研发计划项目(20171BBG70104)
关键词
有柄石韦
化学成分
新绿原酸甲酯
Pyrrosia petiolosa(Christ)Ching
Chemical constituents
Neochlorogenic acid methyl ester
作者简介
欧阳兰(1996-),女,在读硕士研究生,专业方向:中药活性成分及质量标准研究;通讯作者:袁铭铭,Tel:13426688499,E-mail:972988606@qq.com。
