摘要
目的观察丹参酮ⅡA对提高小儿过敏性紫癜(HSP)血浆组织因子途径抑制物(TFPI)水平的作用,为干预肾损害的新靶点、新手段提供科学依据。方法将89例HSP患儿随机分为对照组45例和治疗组44例,对照组采用常规治疗方法,治疗组在对照组治疗方法的基础上加用丹参酮ⅡA注射液静脉滴注,2组均治疗7 d为1个疗程,1个疗程后统计疗效。结果治疗前2组血浆TFPI水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组TFPI水平均显著上升(P<0.01),且治疗组上升幅度优于对照组(P<0.05)。2组随访6月,对照组并发肾炎18例(40.0%),治疗组9例(20.0%),2组比较,差异有统计学意义(P<0.05)。随访6月,2组并发肾炎患儿血浆TFPI水平经t检验,差异无统计学意义(P>0.05)。2组治疗过程中均无不良反应发生。结论采用丹参酮ⅡA辅助治疗小儿HSP,可提高患儿血浆TFPI水平,干预肾损害。
Objective To observe the effect of tanshinone ⅡA in improving the plasma levels of tissue factor pathway inhibitor(TFPI)in children with henoch schonlein purpura(HSP),and to provide scientific basis for intervention of new targets and new means of renal damage.Methods 89 children with HSP were randomly divided into control group(45 cases)and therapy group(44 cases),the control group received routine treatment,while the therapy group was given intravenous drip of tanshinone ⅡA on the basis of the control group’s treatment.Both groups were treated for 7 days as a course,and statistical results were obtained after 1 course of treatment.Results There was no significant difference in the level of TFPI between the 2 groups before treatment(P>0.05),which was comparable;after treatment,the levels of TFPI in the 2 groups increased significantly(P<0.01),and the rising range in the therapy group was better than that in the control group(P<0.05).The 2 groups were followed up for 6 months,18 cases(40.0%)of nephritis in the control group,9 cases(20.0%)in the treatment group,the difference was statistically significant in 2 groups(P<0.05).Follow up for 6 months,plasma TFPI levels in two groups of children with nephritis were not statistically significant(P>0.05)by t test.No adverse reactions occurred in both groups.Conclusion The use of tanshinoneⅡA in adjuvant treatment of HSP in children can improve plasma TFPI level and interfere with renal damage.
作者
胥会英
童晓
李成万
XU Huiying;TONG Xiao;LI Chengwan(Department of Pediatrics,Wuxi Hospital of Integrated Chinese and Western Medicine,Wuxi,Jiangsu,214041,China)
出处
《中医儿科杂志》
2018年第4期26-28,共3页
Journal of Pediatrics of Traditional Chinese Medicine
关键词
过敏性紫癜
小儿
丹参酮ⅡA注射液
组织因子途径抑制物
肾损害
henoch schonlein purpura
children
tanshinone ⅡA injection
tissue factor pathway inhibitor
renal damage
作者简介
胥会英(1981-),女,主治医师,医学硕士,主要从事儿内科临床工作。
