摘要
目的探讨海南省琼海市乙肝母婴阻断成功率调查及相关预测因素。方法选取调查琼海市乙肝病毒表面抗原(HBsAg)阳性新生儿268例,统计母婴阻断成功率,并通过单因素、多因素分析乙肝母婴阻断成功相关预测因素。结果琼海市母亲HBsAg阳性新生儿268例,母亲单阳性占77.61%,双阳性占22.39%;其中母婴阻断成功89.93%、失败10.07%;Logistic回归方程分析,母亲HBV双阳性感染、母体HBV DNA载量、父亲乙肝感染、顺产、母乳喂养均为母婴阻断失败的危险因素,孕期HBIG联合免疫、首针疫苗及时接种、HepB接种剂量为保护因素(P<0.05)。结论海南省琼海市是我国乙肝高流行区,母婴阻断虽取得良好效果,但受母亲HBV双阳性感染、母体HBV DNA载量、父亲乙肝感染、顺产、母乳喂养等因素影响,仍存在阻断失败现象,而加强围生期免疫措施是促进母婴阻断成功的重要举措。
Objective:To investigate the success rate of mother-to-child hepatitis B blocking in Qionghai City,Hainan Province and related predictive factors.Methods:268 newborns with positive hepatitis B virus surface antigen(HBsAg)were selected and investigated in Qionghai.The success rate of mother-infant blockade was calculated,and the predictive factors related to the success of mother-infant blockade of hepatitis B were analyzed by single factor and multiple factors.Results:There were 268 newborns with HBsAg positive mothers in Qionghai,single-positive mothers accounted for 77.61%,and double-positive mothers accounted for 22.39%.Among them,89.93%were successful in mother-to-child blockade and 10.07%failed.Logistic regression analysis showed that maternal HBV double-positive infection,maternal HBV DNA load,father′s hepatitis B infection,normal delivery,and breastfeeding were all risk factors for failure of maternal and infant blockade.HBIG combined immunization during pregnancy,timely vaccination of the first dose of vaccine,and HepB vaccination dose were protective factors(P<0.05).Conclusion:Qionghai City,Hainan Province is a high endemic area for hepatitis B in my country.Although maternal and infant blockade has achieved good results,it still fails due to factors such as maternal HBV double-positive infection,maternal HBV DNA load,father′s hepatitis B infection,normal delivery,and breastfeeding.Strengthening perinatal immune measures is an important measure to promote the success of mother-to-child blockade.
作者
陈玉琴
陈春秋
王华
CHEN Yu-qin;CHEN Chun-qiu;WANG Hua(Qionghai Maternal and Child Health Care Hospital,Qionghai,Hainan,571400)
出处
《中国优生与遗传杂志》
2020年第9期1090-1093,共4页
Chinese Journal of Birth Health & Heredity
基金
海南省医药卫生科研项目:1326361.10A2017
关键词
琼海市
乙肝
母婴阻断
高流行区
母乳喂养
Qionghai City
Hepatitis B
Mother-to-child blockade
High-endemic area
Breastfeeding
