摘要
目的:探究更昔洛韦联合利巴韦林治疗小儿流行性腮腺炎的疗效及对患者相关血清指标的影响。方法:选取2016年9月—2017年9月我院收治的流行性腮腺炎患儿60例,依据治疗方案的不同分为对照组和治疗组,各30例。对照组接受利巴韦林注射液(10 mg/kg溶于200 mL0.9%氯化钠注射液中,静脉滴注,qd)治疗,在此基础上,治疗组给予更昔洛韦注射液(5 mg/kg加到100 mL5%葡萄糖注射液中静脉滴注,bid)治疗。比较两组治疗效果、炎症指标、主要症状消退时间及不良反应发生情况。结果:治疗组总有效率高于对照组,差异有统计学意义(P<0.05);治疗后,治疗组CRP、IL-6、TNF-α低于对照组,差异有统计学意义(P<0.05);治疗组腮肿、退热及腺体疼痛的消退时间短于对照组,差异有统计学意义(P<0.01);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:更昔洛韦联合利巴韦林治疗小儿流行性腮腺炎的疗效良好,可显著缩短腮肿、退热及腺体疼痛的消退时间,减轻机体微炎症状态。
Objective:To investigate the efficacy of ganciclovir combined with ribavirin in the treatment of pediatric epidemic mumps and its effect on serum related indexes.Methods:60 children with epidemic mumps admitted to our hospital from September 2016 to September 2017 were selected and divided into a control group and a treatment group according to different treatment regimens,30 cases each.The patients in the control group received ribavirin injection(10 mg/kg dissolved in 200 mL of 0.9%sodium chloride injection,intravenous drip,qd).On this basis,the patients in the treatment group were further treated with ganciclovir injection(5 mg/kg was added to 100 mL 5%glucose injection,intravenous drip,bid).The therapeutic effect,inflammation indexes,the time of major symptom regression and adverse reactions were compared between the two groups.Results:The total effective rate in the treatment group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of CRP,IL-6 and TNF-αin the treatment group were lower than those in the control group,and the differences were statistically significant(P<0.05).The time of mums regression,the time of fever regression and the time of glandular pain regression in the treatment group were shorter than those in the control group,and the differences were statistically significant(P<0.01).There was no statistically significant differnce in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Ganciclovir combined with ribavirin is effective in treating mumps in children,which can significantly shorten the time of blowing,fever and glandular pain and reduce the microinflammation in the children.
作者
孟晓晖
Meng Xiao-hui(Department of Stomatology,Xuchang People’s Hospital,Xuchang Henan 461000,China)
出处
《中国合理用药探索》
CAS
2019年第11期28-31,共4页
Chinese Journal of Rational Drug Use
作者简介
孟晓晖,女,副主任医师。研究方向:口腔隐形矫治,口腔正畸与牙周的关系等。E-mail:gaoshujuan2257@163.com
