摘要
β-肾上腺素能受体(β-adrenergic receptor,β-AR)是一种G蛋白偶联受体,表达于多种肿瘤细胞上,其中以β2-AR亚型为主。儿茶酚胺与β-AR相互作用可通过多种途径促进肿瘤细胞的增殖、凋亡、侵袭及迁移,从而影响肿瘤的发生和发展。近期研究发现,β-AR也广泛表达于免疫细胞上,并可通过调控免疫细胞的功能影响肿瘤免疫微环境进而影响肿瘤的发生和发展。临床研究发现,β-AR的表达与肿瘤患者的预后密切相关,应用β-AR阻滞剂既能降低部分肿瘤患者的死亡率,又具有降低化疗的耐药性、提高放疗敏感性、与免疫检查点抑制剂协同抗肿瘤作用,因此靶向β-AR是肿瘤治疗的新选择。本文将就β-AR在肿瘤发生和发展中的作用作一综述。
β-adrenergic receptor(β-AR)is a G-protein coupled receptor which is expressed in a variety of tumor cells,withβ2-AR being the major type ofβ-AR expressed in tumor cells.The interaction between catecholamine andβ-AR can promote the proliferation,apoptosis,invasion and migration of tumor cells through a variety of ways,thus affecting the occurrence and development of tumor.Recent studies have found thatβ-AR is also widely expressed in immune cells,and can affect the tumor immune microenvironment by regulating the function of immune cells,and then affect the occurrence and development of tumors.Clinical studies have found that the expression ofβ-AR is closely related to the prognosis of tumor patients.β-AR blockers can not only reduce the mortality of some tumor patients,but also counteract the drug resistance of chemotherapy,improve the sensitivity of radiotherapy and cooperate with immune checkpoint inhibitors.Targetingβ-AR may be a new choice for tumor therapy.This article reviews the role ofβ-AR in tumorigenesis and development.
作者
李晓燕
李亚星
贾漪涛
LI Xiaoyan;LI Yaxing;JIA Yitao(Third Department of Oncology,Heibei General Hospital,Shijiazhuang 050051,Hebei Province,China;Graduate School of Hebei North University,Zhangjiakou 075000,Hebei Province,China)
出处
《肿瘤》
CAS
CSCD
北大核心
2021年第9期650-656,共7页
Tumor
作者简介
Correspondence to:贾漪涛,E-mail:jiayitao99@163.com
