摘要
21世纪初始,胃癌治疗已从单一手术模式逐渐向以手术为主的综合治疗模式转变。其中,局部进展期胃癌围手术期治疗的临床意义受到极大关注。新辅助化疗是在恶性肿瘤局部治疗(手术或放疗)前给予的全身化疗,旨在使肿瘤临床降期、提高根治术切除率、减灭微小转移灶,并且检测自体对化疗药物的敏感性等。本文对近年来国内外学者尤其是中国学者在胃癌新辅助化疗领域开展的重点临床研究和探索进行综述,并且对未来的发展方向进行展望,以期为中国胃癌新辅助化疗临床研究的开展提供参考。
At the beginning of the 21st century,the treatment of gastric cancer has gradually changed from a single surgical mode to a comprehensive surgical mode.Among them,the clinical significance of perioperative treatment of locally advanced gastric cancer(LAGC)has received great attention.Neoadjuvant chemotherapy(NACT)refers to the systemic chemotherapy given before local treatment(surgery or radiotherapy)of malignant tumor,which aims to reduce the clinical stage of tumor,improve the radical resection rate,reduce the micrometastasis,and detect the sensitivity of autologous to chemotherapy drugs.In this paper,the key clinical research and exploration of domestic and foreign scholars,especially Chinese scholars in the field of neoadjuvant chemotherapy for gastric cancer in recent years are reviewed,and the future development direction is prospected,in order to provide references for the clinical research of neoadjuvant chemotherapy for gastric cancer in China.
作者
曾奕
邓靖宇
ZENG Yi;DENG Jingyu(Department of Gastric Cancer,Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cancer,Tianjin Key Laboratory of Cancer Prevention and Treatment,Tianjin Cancer Clinical Research Center,Tianjin,300060,China;Department of Gastrointestinal Surgical Oncology,Fujian Cancer Hospital&Fujian Medical University Cancer Hospital,Fuzhou 350014,Fujian Province,China)
出处
《肿瘤》
CAS
CSCD
北大核心
2022年第5期305-313,共9页
Tumor
基金
国家重点研发计划“精准医学研究”重点专项(2017YFC0908300)
国家重点研发计划“重大慢性非传染性疾病防控研究”重点专项(MOST-2016YFC1303202)
国家自然科学基金(81974373,81572372)
福建省卫生健康面向农村和城市社区推广适宜技术项目(2019006)
福建医科大学启航基金项目(2017Q1219)
关键词
胃癌
局部进展期胃癌
围手术期治疗
新辅助化疗
Gastric cancer
Locally advanced gastric cancer
Periope-rative treatment
Neoadjuvant chemotherapy
作者简介
Correspondence to:邓靖宇,E-mail:dengery@126.com
