摘要
临床上针对胰腺癌常用的血清学肿瘤标志物包括CA199、CA125、CA50、CEA和AFP等。其中,CA199最为常用,是反映肿瘤整体负荷的一项指标;CA125是反映肿瘤转移相关负荷的指标。联合检测血清学肿瘤标志物有助于在出现影像学改变前早期诊断胰腺癌,同时通过检测血清肿瘤标志物的变化,对新辅助化疗、手术治疗以及术后综合治疗等各个治疗阶段的疗效进行评价,并为后续治疗方式的选择提供参考依据。在后期随访中,通过监测血清学肿瘤标志物的变化,可以及时发现肿瘤早期局部复发和远处转移。此外,合理应用血清学肿瘤标志物,还有助于筛选出能够真正获益于根治性切除术的患者,把握交界可切除胰腺癌的手术时机。
The commonly used serological tumor markers for pancreatic cancer include CA199,CA125,CA50,CEA,AFP,and so on,of which CA199 is the most commonly used index to reflect the overall tumor load,while CA125 is an index to reflect the tumor metastasis-related load.Combined detection of serological tumor markers is helpful for early diagnosis of pancreatic cancer before imaging changes,and by detecting the changes of serum tumor markers,it can evaluate the efficacy of neoadjuvant chemotherapy,surgery,postoperative comprehensive treatment,and other stages of treatment,and provide reference and basis for the selection of follow-up treatment.In the late follow-up,early local recurrence and distant metastasis of the tumor can be detected in time by monitoring the changes of serological tumor markers.In addition,the rational use of serological tumor markers can also help to screen out patients who can really benefit from radical resection and to grasp the timing of surgery for resectable pancreatic cancer.
作者
贾沁园
刘巍
JIA Qinyuan;LIU Wei(Department of Biliary-Pancreatic Surgery,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China)
出处
《肿瘤》
CAS
CSCD
北大核心
2022年第11期766-771,共6页
Tumor
作者简介
Correspondence to:刘巍,E-mail:sugliuwei2004@126.com
