摘要
目的探讨自拟中药方对耐多药肺结核的影响。方法将2020年7月至2021年12月河南省传染病医院收治的92例耐多药肺结核患者随机分为观察组和对照组,各46例。对照组接受常规治疗方案,观察组在此基础上联合自拟中药治疗,均进行6个月耐多药肺结核强化治疗。评价两组病灶吸收和痰菌转阴情况,检测CD3^(+)、CD4^(+)、CD8^(+)等T淋巴细胞亚群指标以及白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)等细胞因子指标,并记录不良反应例数。结果观察组患者治疗后病灶吸收情况优于对照组,并且治疗3个月和6个月的痰菌转阴率(分别为47.83%和76.09%)高于对照组(分别为26.09%和56.52%),差异均有统计学意义(P<0.05)。两组强化治疗后CD3^(+)、CD4^(+)升高,CD8^(+)、IL-6和TNF-α降低,并且观察组上述T淋巴细胞亚群和细胞因子水平的改善程度高于对照组,差异均有统计学意义(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。结论自拟中药方辅助治疗能够有效调节耐多药肺结核患者的免疫状态,促进病灶吸收和痰菌转阴,治疗效果和安全性均可得到保证。
Objective To explore the effect of self-prepared Chinese prescription on patients with multidrug-resistant pulmonary tuberculosis.Methods A total of 92 patients with multidrug-resistant pulmonary tuberculosis admitted to Henan Infectious Disease Hospital from July 2020 to December 2021 were selected and randomly divided into observation group and control group,with 46 cases in each group.The control group received conventional treatment,and the observation group was combined with self-designed self-prepared Chinese prescription on this basis,and all patients received intensive treatment for 6 months.Lesion absorption and sputum negative conversion of the two groups were evaluated,T lymphocyte subsets of CD3^(+),CD4^(+),CD8^(+)and cytokines of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)were detected,and the number of adverse reactions was recorded.Results The lesion absorption in the observation group was better after intensive treatment,and the sputum negative conversion rates(47.83%and 76.09%,respectively)after 3 months and 6 months were higher than those in the control group(26.09%and 56.52%,respectively)after intensive treatment(P<0.05).After intensive treatment,CD3^(+)and CD4^(+)were increased,while CD8^(+),IL-6 and TNF-αwere decreased,and the improvement degree of T lymphocyte subsets and cytokines in the observation group was higher(P<0.05).There was no significant difference in the incidence of adverse reactions between observation group(5 cases,10.87%)and control group(7 cases,15.22%)(P>0.05).Conclusion The adjuvant treatment of self-designed Chinese prescription could effectively regulate the immune status of patients with multidrug-resistant pulmonary tuberculosis,promote lesion absorption and sputum negative,and the therapeutic effect and safety could be guaranteed.
作者
张志杰
侯明杰
ZHANG Zhijie;HOU Mingjie(Department of Tuberculosis Minimally Invasive Diagnosis and Treatment,Henan Infectious Disease Hospital,Zhengzhou 450000,China;the First Ward of Infection Department,Henan Infectious Disease Hospital,Zhengzhou 450000,China)
出处
《河南医学研究》
2025年第5期915-918,共4页
Henan Medical Research
关键词
耐多药肺结核
中药
T淋巴细胞亚群
安全性
multidrug-resistant pulmonary tuberculosis
Chinese prescription
T lymphocyte subsets
safety
