摘要
本文通过对近5年针刺治疗抑郁症的机制研究进行概括归纳,发现针刺可通过提高脑源性神经营养因子及单胺类递质等的表达,有效增强突触传递和可塑;能够通过调控半胱氨酸蛋白酶-3、B淋巴细胞瘤-2家族的表达,有效抑制细胞凋亡的发生;通过抑制促炎因子白细胞介素-1β的增加、胶质细胞的过度活化,来调控中枢炎性反应的发生;通过调控相关激素水平的表达,良性调节下丘脑—垂体—肾上腺轴,减轻海马神经元等的受损;通过调节肠道菌群以及信号通路的表达等途径来治疗抑郁症。研究表明,针刺对于抑郁症的干预具有多途径、多靶点综合调控的特点。在今后的研究中,可加强针刺治疗疾病的临床应用;拓展穴位选用范围,加强体穴的应用频次;也应拓展对针刺穴位的研究,探索最佳针刺腧穴及操作的定量参数;同时要更加深入地探索针刺各机制间的相互关联性,加快基础机制研究,以便更好地指导临床。
In this paper,the mechanism of acupuncture therapy for depression in the past five years was summarized It was found that acupuncture can effectively enhance synaptic transmission and plasticity by increasing the expression of brain-derived neurotrophic factor(BDNF)and monoamine transmitters.By regulating the expressions of Caspase-3 and B-cell Lymphoma-2(Bacl-2),cell apoptosis was inhibited effectively.By inhibiting the increase of the pro-inflammatory factor interleukin-1β(IL-1β)and the over-activation of glial cells,the central inflammatory response was regulated.By regulating the expression of related hormone levels,benign regulation of HPA axis can reduce the damage of hippocampal neurons.Depression can be treated by regulating the expression of intestinal flora and signaling pathways.The study shows that acupuncture therapy has the characteristics of multi-channel and multi-target comprehensive regulation for depression intervention,which can strengthen the clinical application of acupuncture in the treatment of diseases in the future research.Expand the selection range of acupoints and strengthen the application frequency of body points;and for acupuncture points should also expand the research,explore the best acupuncture acupoints and the best quantitative parameters of operation;at the same time,it is necessary to further explore the correlation between acupuncture mechanisms,accelerate the basic mechanism research,so as to better guide clinical.
作者
周明园
吕晓琳
黄飞
蒋焕莹
洛子茹
焦雪峰
孙美琦
孙忠人
尹洪娜
ZHOU Mingyuan;LYU Xiaolin;HUANG Fei;JIANG Huanying;LUO Ziru;JIAO Xuefeng;SUN Meiqi;SUN Zhongren;YIN Hongna(Heilongjiang University of Chinese Medicine,Harbin 150040,China)
出处
《环球中医药》
CAS
2023年第10期2121-2126,共6页
Global Traditional Chinese Medicine
基金
国家中医药管理局中医药循证能力建设项目(2019XZZX-ZJ005)。
关键词
针刺
抑郁症
类抑郁大鼠模型
作用机制
突触传递和重塑
细胞凋亡
炎症反应
acupuncture
major depressive disorder
depression-like rat model
mechanism of action
synaptic transmission and remodeling
cell apoptosis
inflammatory response
作者简介
周明园(1997-),2021级在读硕士研究生。研究方向:针灸防治脑脊髓神经病的研究。E-mail:3236503080@qq.com;通信作者:尹洪娜(1979-),博士,主任医师,博士生导师。研究方向:针灸防治脑脊髓神经病的研究。E-mail:hljtcmacu@163.com;黄飞,硕士研究生;蒋焕莹,硕士研究生;洛子茹,硕士研究生;焦雪峰,硕士研究生;孙美琦,硕士研究生。
